(+)-Borneol

Modify Date: 2024-01-02 12:26:34

(+)-Borneol structure	Common Name	(+)-Borneol
	CAS Number	464-43-7	Molecular Weight	154.249
	Density	1.0±0.1 g/cm3	Boiling Point	212.0±0.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₈O	Melting Point	206-209ºC(lit.)
	MSDS	Chinese USA	Flash Point	80.7±10.9 °C
	Symbol	GHS02	Signal Word	Warning

Use of (+)-Borneol

(+)-Borneol (d-Borneol) is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM.

Name	(+)-borneol
Synonym	More Synonyms

Description	(+)-Borneol (d-Borneol) is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Inflammation/Immunology Natural Products >> Terpenoids and Glycosides
Target	EC50: 248 μM (GABA receptor)[1]
In Vitro	(+)-Borneol is present in the essential oils of numerous medicinal plants, including valerian (Valeriana officinalis), chamomile (Matricaria chamomilla) and lavender (Lavandula officinalis). Extracts of these plants are used traditionally to relieve anxiety, restlessness and insomnia. (+)-Borneol is found to have a highly efficacious positive modulating action at GABAA receptors. (+)-Borneol enhances the action of low concentrations of GABA by more than 1000% (EC50=248 μM)[1].
In Vivo	(+)-Borneol has remarkable anti-hyperalgesic effects on neuropathic and inflammatory pain in animal models. Both oral administration (125, 250 or 500 mg/kg) and intrathecal injection (i.t.) (15, 30 and 60 μg) of (+)-Borneol reduce mechanical hypersensitivity dose-dependently in SNL and CFA models. The antihyperalgesic effects of (+)-Borneol are abolished by a selective GABAA receptor (GABAAR) antagonist bicuculline. (+)-Borneol (500 mg/kg, p.o. or 60 μg, i.t.) does not influence motor function[2]. After per oral application, (+)-Borneol is absorbed rapidly into the brain and could be determined 5 min after dosing. The maximal brain concentration (86.52 μg/g) is reached after 1 h post-dosing. (+)-Borneol could affect the contents of AA neurotransmitters in mice brain and the change in excitatory ratio leads to borneol's double side effects on the central nervous system[3].
Animal Admin	Mice: Inflammatory pain is induced by injection of Complete Freund's adjuvant (CFA, 1 mg/mL). Ten min later mice are treated with (+)-Borneol (125, 250, 500 mg/kg) or vehicle. Mechanical hypersensitivity is then measured[2].
References	[1]. Granger RE, et al. (+)- And (-)-borneol: efficacious positive modulators of GABA action at human recombinantalpha1beta2gamma2L GABA(A) receptors. Biochem Pharmacol. 2005 Apr 1;69(7):1101-11. [2]. Jiang J, et al. (+)-Borneol alleviates mechanical hyperalgesia in models of chronic inflammatory and neuropathic pain in mice. Eur J Pharmacol. 2015 Jun 15;757:53-8.

Density	1.0±0.1 g/cm3
Boiling Point	212.0±0.0 °C at 760 mmHg
Melting Point	206-209ºC(lit.)
Molecular Formula	C₁₀H₁₈O
Molecular Weight	154.249
Flash Point	80.7±10.9 °C
Exact Mass	154.135757
PSA	20.23000
LogP	2.71
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.502

(+)-Borneol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ED7060000

CHEMICAL NAME :: Borneol, (1R,2S,4R)- (+)-

CAS REGISTRY NUMBER :: 464-43-7

BEILSTEIN REFERENCE NO. :: 2038056

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H18-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,204,1989

Symbol	GHS02
Signal Word	Warning
Hazard Statements	H228
Precautionary Statements	P210
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	F: Flammable;
Risk Phrases	R11
Safety Phrases	16-33-36-7/9
RIDADR	UN 1312
WGK Germany	3
RTECS	ED7060000
Packaging Group	III
Hazard Class	4.1
HS Code	2906199090

Precursor 0
DownStream 10
CAS#:32511-34-5 (R)-(+)-Bornylamine CAS#:464-48-2 (±)-Camphor CAS#:20279-31-6 (1,7,7-trimethy... CAS#:20279-25-8 Borneol, propionate
CAS#:565-00-4 Camphene CAS#:76-22-2 (+/-)-Camphor CAS#:464-49-3 (+)-Camphor CAS#:79-92-5 (+)-Camphene
CAS#:76-49-3 (+)-Bornyl acetate CAS#:6627-72-1 DL-2-Bornanol

HS Code	2906199090
Summary	2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Kinetics and mechanisms of the tropospheric reactions of menthol, borneol, fenchol, camphor, and fenchone with hydroxyl radicals (OH) and chlorine atoms (Cl).

J. Phys. Chem. A 116(16) , 4097-107, (2012)

Relative kinetic techniques have been used to measure the rate coefficients for the reactions of oxygenated terpenes (menthol, borneol, fenchol, camphor, and fenchone) and cyclohexanol with hydroxyl r...

Treatment with cardiotonic pills(®) after ischemia-reperfusion ameliorates myocardial fibrosis in rats.

Microcirculation 20(1) , 17-29, (2013)

The present study was designed to evaluate whether CP was beneficial in alleviating myocardial fibrosis following I/R injury.Sprague-Dawley rats were subjected to 30 minutes occlusion of the LADCA, fo...

Borneol alleviates oxidative stress via upregulation of Nrf2 and Bcl-2 in SH-SY5Y cells.

Pharm. Biol. 51(1) , 30-5, (2013)

The β-amyloid (Aβ) peptide aggregation with accompanying oxidative stress plays the major role in the pathogenesis of Alzheimer's disease (AD). Some natural compounds, including borneol, shed promisin...

oct-7-ene-2,5-dione

Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, (2S)-

oct-7-en-2,5-dion

EINECS 207-352-6

(2S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol

(+)-BORNEOL

MFCD00066427

BioBioPha
China
Product Name: (+)-Borneol
Price: ￥Inquiry/50mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: (+)-Borneol
Price: ￥938.0/25g ￥2038.0/5g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

Henan Tianfu Chemical Co., Ltd.
China
Product Name: tianfu-chem_(+)-BORNEOL,464-43-7
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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(+)-Borneol

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