TLR2-IN-C29
Modify Date: 2025-08-21 18:09:45
TLR2-IN-C29 structure
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Common Name | TLR2-IN-C29 | ||
|---|---|---|---|---|
| CAS Number | 363600-92-4 | Molecular Weight | 285.2988 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H15NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TLR2-IN-C29C29 is a Toll-like receptor 2 (TLR2) inhibitor. |
| Name | TLR2-IN-C29 |
|---|---|
| Synonym | More Synonyms |
| Description | C29 is a Toll-like receptor 2 (TLR2) inhibitor. |
|---|---|
| Related Catalog | |
| Target |
TLR2[1] |
| In Vitro | C29 blunts hTLR2/1 and hTLR2/6 signaling in HEK-TLR2 Stable transfectants and THP-1 Cells. C29 blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 also inhibits P3C- and P2C-induced IL-1β gene expression significantly at both 1 h and 4 h following stimulation, as well as both P3C- and P2C-induced NF-κB–luciferase activity in transiently transfected HEK293T cells expressing hTLR2 and an NF-κB–sensitive luciferase reporter construct. C29 preferentially inhibits TLR2/1 signaling in primary murine macrophages. C29 blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 Cells and murine macrophages. C29 inhibits ligand-induced interaction of TLR2 with MyD88 and blocks MAPK and NF-κB activation[1]. |
| References |
[1]. Vogel S, et al. Small molecule inhibitors of tlr2 signaling. WO2016164414A1 |
| Molecular Formula | C16H15NO4 |
|---|---|
| Molecular Weight | 285.2988 |
| InChIKey | WTGMGRFVBFDHGQ-UHFFFAOYSA-N |
| SMILES | COc1cccc(C=Nc2cccc(C(=O)O)c2C)c1O |
| Storage condition | 2-8℃ |
| C29 |