Trimethylcolchicinic acid

Modify Date: 2024-01-19 06:12:20

Trimethylcolchicinic acid structure	Common Name	Trimethylcolchicinic acid
	CAS Number	3482-37-9	Molecular Weight	343.37400
	Density	1.32g/cm3	Boiling Point	629ºC at 760mmHg
	Molecular Formula	C₁₉H₂₁NO₅	Melting Point	>230ºC (dec.)
	MSDS	Chinese USA	Flash Point	334.2ºC
	Symbol	GHS07	Signal Word	Warning

Use of Trimethylcolchicinic acid

Trimethylcolchicinic acid is an antimitotic agent disrupting microtubule action through the binding of tubulin and preventing polymerization. Has been shown to stimulate the intrinsic GTPase activity of tubulin. Induces apoptosis and activates the JNK/SAPK signals.

Name	N-Deacetyl Colchiceine
Synonym	More Synonyms

Density	1.32g/cm3
Boiling Point	629ºC at 760mmHg
Melting Point	>230ºC (dec.)
Molecular Formula	C₁₉H₂₁NO₅
Molecular Weight	343.37400
Flash Point	334.2ºC
Exact Mass	343.14200
PSA	91.01000
LogP	3.09150
Index of Refraction	1.628
Storage condition	−20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0960000

CHEMICAL NAME :: Colchicinic acid, trimethyl-

CAS REGISTRY NUMBER :: 3482-37-9

BEILSTEIN REFERENCE NO. :: 3008992

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C19-H21-N-O5

MOLECULAR WEIGHT :: 343.41

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JZ NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

REFERENCE :: CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 3,134,1950

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H332
Precautionary Statements	P280
Hazard Codes	Xn: Harmful;
Risk Phrases	20/21/22
Safety Phrases	36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	GH0960000

Precursor 7
CAS#:64-86-8 Colchicine CAS#:477-27-0 Colchiceine CAS#:73307-44-5 (+/-)-N-deacety... CAS#:7469-68-3 7-(benzylidenea...
CAS#:7664-93-9 Sulfuric acid CAS#:7647-01-0 Hydrochloric acid CAS#:67-56-1 Methanol
DownStream 7
CAS#:3476-50-4 Trimethylcolchi... CAS#:47477-04-3 (7S)-7-amino-1,... CAS#:477-27-0 Colchiceine CAS#:477-30-5 (-)-Demecolcine
CAS#:1850-57-3 5,6-Dihydro-1,2... CAS#:518-11-6 COLCHICEINE, N-... CAS#:75520-89-7 (+)-Colchicin

Resolution of liver fibrosis in chronic CCl4 administration in the rat after discontinuation of treatment: effect of silymarin, silibinin, colchicine and trimethylcolchicinic acid.

Basic Clin Pharmacol Toxicol. 96(5) , 375-80, (2005)

The purpose of this work was to obtain a suitable model of fibrosis, in which spontaneous reversion was minimal, to study the ability of silymarin, silibinin, colchicine and trimethylcolchicinic acid ...

Effect of colchicine and trimethylcolchicinic acid on CCl4-induced cirrhosis in the rat.

Pharmacol. Toxicol. 79(5) , 241-6, (1996)

Colchicine is one of the most promising drugs for the treatment of cirrhosis. However, due to its toxicity, other drugs are being evaluated and colchicine-like molecules may be good alternatives. The ...

The role of microtubules in pinocytosis. Inhibition of fluid-phase pinocytosis in the rat visceral yolk sac by mitoclasic and related agents.

Cell Biol. Int. Rep. 7(8) , 593-602, (1983)

Colchicine, demecolcine and vinblastine all effectively inhibited the pinocytic capture of 125I-labelled poly(vinylpyrrolidone) by rat visceral yolk sacs cultured in vitro. Complete inhibition did not...

trimethylcolchicinic acid

DC Chemicals Limited
China
Product Name: Trimethylcolchicinic acid
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-, (7S)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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