COLCHICEINE, N-DEACETYL-N-METHYL-

Modify Date: 2025-08-31 19:06:06

COLCHICEINE, N-DEACETYL-N-METHYL- structure	Common Name	COLCHICEINE, N-DEACETYL-N-METHYL-
	CAS Number	518-11-6	Molecular Weight	357.40000
	Density	1.27g/cm3	Boiling Point	626.4ºC at 760 mmHg
	Molecular Formula	C₂₀H₂₃NO₅	Melting Point	N/A
	MSDS	N/A	Flash Point	332.6ºC

Name	(7S)-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
Synonym	More Synonyms

Density	1.27g/cm3
Boiling Point	626.4ºC at 760 mmHg
Molecular Formula	C₂₀H₂₃NO₅
Molecular Weight	357.40000
Flash Point	332.6ºC
Exact Mass	357.15800
PSA	77.02000
LogP	3.04280
Index of Refraction	1.608
InChIKey	ATWWYGQDYGSWQA-AWEZNQCLSA-N
SMILES	CNC1CCc2cc(OC)c(OC)c(OC)c2-c2ccc(O)c(=O)cc21

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0600000

CHEMICAL NAME :: Colchiceine, N-deacetyl-N-methyl-

CAS REGISTRY NUMBER :: 518-11-6

LAST UPDATED :: 198712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H23-N-O5

MOLECULAR WEIGHT :: 357.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

Precursor 5
CAS#:477-30-5 (-)-Demecolcine CAS#:64-86-8 Colchicine CAS#:3476-50-4 Trimethylcolchi... CAS#:477-27-0 Colchiceine
CAS#:3482-37-9 Trimethylcolchi...
DownStream 2
CAS#:4702-33-4 Isodemecolcine CAS#:477-30-5 (-)-Demecolcine

Demecolcein

(S)-10-hydroxy-1,2,3-trimethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-one

demecolceine

(7s)-9-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-10(5h)-one

(S)-10-Hydroxy-1,2,3-trimethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-on

N-Desacetyl-N-methylcolchiceine

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Product Name: COLCHICEINE, N-DEACETYL-N-METHYL-
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Purity: 98.0%
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