(+)-Colchicin

Modify Date: 2024-01-05 18:35:00

(+)-Colchicin Structure
(+)-Colchicin structure
 Common Name (+)-Colchicin
CAS Number 75520-89-7 Molecular Weight 399.43700
Density 1.25g/cm3 Boiling Point 726ºC at 760 mmHg
Molecular Formula C22H25NO6 Melting Point 106-132ºC
MSDS N/A Flash Point 392.9ºC

 Names

Name N-[(7R)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.25g/cm3
Boiling Point 726ºC at 760 mmHg
Melting Point 106-132ºC
Molecular Formula C22H25NO6
Molecular Weight 399.43700
Flash Point 392.9ºC
Exact Mass 399.16800
PSA 83.09000
LogP 3.26250
Index of Refraction 1.584

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GH0705000
CHEMICAL NAME :
Colchicine, (+)-
CAS REGISTRY NUMBER :
75520-89-7
LAST UPDATED :
199409
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C22-H25-N-O6
MOLECULAR WEIGHT :
399.48
WISWESSER LINE NOTATION :
L B677 MV&T&J CO1 DO1 EO1 JMV1 NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
49 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981

 Synthetic Route

(+/-)-N-deacetylcolchiceine structure

(+/-)-N-deacety...

CAS#:73307-44-5

~%

(+)-Colchicin Structure

(+)-Colchicin

CAS#:75520-89-7
Literature: Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521
N-(1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide structure

N-(1,2,3,10-tet...

CAS#:209810-38-8

~%

(+)-Colchicin Structure

(+)-Colchicin

CAS#:75520-89-7
Literature: Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521
7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one structure

7-amino-1,2,3,1...

CAS#:102491-73-6

~%

(+)-Colchicin Structure

(+)-Colchicin

CAS#:75520-89-7
Literature: Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521
(R/S)-N-Deacetyl Colchiceine N-Trifluroracetate structure

(R/S)-N-Deacety...

CAS#:102491-70-3

~%

(+)-Colchicin Structure

(+)-Colchicin

CAS#:75520-89-7
Literature: Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521
(+/-)-N-(trifluoroacetyl)deacetylcolchicine structure

(+/-)-N-(triflu...

CAS#:102491-71-4

~%

(+)-Colchicin Structure

(+)-Colchicin

CAS#:75520-89-7
Literature: Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521
Trimethylcolchicinic acid structure

Trimethylcolchi...

CAS#:3482-37-9

~%

(+)-Colchicin Structure

(+)-Colchicin

CAS#:75520-89-7
Literature: Roesner, Manfred; Capraro, Hans-Georg; Jacobson, Arthur E.; Atwell, Louise; Brossi, Arnold; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 257 - 261
diazomethane structure

diazomethane

CAS#:186581-53-3
Colchiceine structure

Colchiceine

CAS#:477-27-0

~%

(+)-Colchicin Structure

(+)-Colchicin

CAS#:75520-89-7
Literature: Roesner et al. Journal of Medicinal Chemistry, 1981 , vol. 24, p. 257,260
diazomethane structure

diazomethane

CAS#:186581-53-3
Colchiceine structure

Colchiceine

CAS#:477-27-0

~%

(+)-Colchicin Structure

(+)-Colchicin

CAS#:75520-89-7

(+)-isocolchicine structure

(+)-isocolchicine

CAS#:102419-93-2
Literature: Roesner, Manfred; Capraro, Hans-Georg; Jacobson, Arthur E.; Atwell, Louise; Brossi, Arnold; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 257 - 261
7-(benzylideneamino)-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one structure

7-(benzylidenea...

CAS#:7469-68-3

~%

(+)-Colchicin Structure

(+)-Colchicin

CAS#:75520-89-7
Literature: Corrodi; Hardegger Helvetica Chimica Acta, 1957 , vol. 40, p. 193,198, 199

 Synonyms

(+)-Colchicin
COLCHICINE,(+)
Acetamide,N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-,(R)
(R)-7-Acetylamino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on
Lopac-C-9754
Colchicine,(R)-Isomer
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