(+)-Colchicin
Names
[ CAS No. ]:
75520-89-7
[ Name ]:
(+)-Colchicin
[Synonym ]:
(+)-Colchicin
COLCHICINE,(+)
Acetamide,N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-,(R)
(R)-7-Acetylamino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on
Lopac-C-9754
Colchicine,(R)-Isomer
Chemical & Physical Properties
[ Density]:
1.25g/cm3
[ Boiling Point ]:
726ºC at 760 mmHg
[ Melting Point ]:
106-132ºC
[ Molecular Formula ]:
C22H25NO6
[ Molecular Weight ]:
399.43700
[ Flash Point ]:
392.9ºC
[ Exact Mass ]:
399.16800
[ PSA ]:
83.09000
[ LogP ]:
3.26250
[ Index of Refraction ]:
1.584
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GH0705000
- CHEMICAL NAME :
- Colchicine, (+)-
- CAS REGISTRY NUMBER :
- 75520-89-7
- LAST UPDATED :
- 199409
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C22-H25-N-O6
- MOLECULAR WEIGHT :
- 399.48
- WISWESSER LINE NOTATION :
- L B677 MV&T&J CO1 DO1 EO1 JMV1 NO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 49 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981