三甲基秋水仙酸结构式
|
常用名 | 三甲基秋水仙酸 | 英文名 | Trimethylcolchicinic acid |
|---|---|---|---|---|
| CAS号 | 3482-37-9 | 分子量 | 343.37400 | |
| 密度 | 1.32g/cm3 | 沸点 | 629ºC at 760mmHg | |
| 分子式 | C19H21NO5 | 熔点 | >230ºC (dec.) | |
| MSDS | 中文版 美版 | 闪点 | 334.2ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
三甲基秋水仙酸用途Trimethylcolchicinic acid is an antimitotic agent disrupting microtubule action through the binding of tubulin and preventing polymerization. Has been shown to stimulate the intrinsic GTPase activity of tubulin. Induces apoptosis and activates the JNK/SAPK signals. |
| 中文名 | 三甲基秋水仙素酸 |
|---|---|
| 英文名 | N-Deacetyl Colchiceine |
| 英文别名 | 更多 |
| 密度 | 1.32g/cm3 |
|---|---|
| 沸点 | 629ºC at 760mmHg |
| 熔点 | >230ºC (dec.) |
| 分子式 | C19H21NO5 |
| 分子量 | 343.37400 |
| 闪点 | 334.2ºC |
| 精确质量 | 343.14200 |
| PSA | 91.01000 |
| LogP | 3.09150 |
| 折射率 | 1.628 |
| 储存条件 | −20°C |
| 符号 |
GHS07 |
|---|---|
| 信号词 | Warning |
| 危害声明 | H302-H312-H332 |
| 警示性声明 | P280 |
| 危害码 (欧洲) | Xn: Harmful; |
| 风险声明 (欧洲) | 20/21/22 |
| 安全声明 (欧洲) | 36 |
| 危险品运输编码 | NONH for all modes of transport |
| WGK德国 | 3 |
| RTECS号 | GH0960000 |
| 三甲基秋水仙酸上游产品 7 | |
|---|---|
| 三甲基秋水仙酸下游产品 7 | |
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Resolution of liver fibrosis in chronic CCl4 administration in the rat after discontinuation of treatment: effect of silymarin, silibinin, colchicine and trimethylcolchicinic acid.
Basic Clin Pharmacol Toxicol. 96(5) , 375-80, (2005) The purpose of this work was to obtain a suitable model of fibrosis, in which spontaneous reversion was minimal, to study the ability of silymarin, silibinin, colchicine and trimethylcolchicinic acid ... |
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Effect of colchicine and trimethylcolchicinic acid on CCl4-induced cirrhosis in the rat.
Pharmacol. Toxicol. 79(5) , 241-6, (1996) Colchicine is one of the most promising drugs for the treatment of cirrhosis. However, due to its toxicity, other drugs are being evaluated and colchicine-like molecules may be good alternatives. The ... |
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The role of microtubules in pinocytosis. Inhibition of fluid-phase pinocytosis in the rat visceral yolk sac by mitoclasic and related agents.
Cell Biol. Int. Rep. 7(8) , 593-602, (1983) Colchicine, demecolcine and vinblastine all effectively inhibited the pinocytic capture of 125I-labelled poly(vinylpyrrolidone) by rat visceral yolk sacs cultured in vitro. Complete inhibition did not... |
| trimethylcolchicinic acid |
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