Trimethylcolchicinic acid
Trimethylcolchicinic acid structure
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Common Name | Trimethylcolchicinic acid | ||
|---|---|---|---|---|
| CAS Number | 3482-37-9 | Molecular Weight | 343.37400 | |
| Density | 1.32g/cm3 | Boiling Point | 629ºC at 760mmHg | |
| Molecular Formula | C19H21NO5 | Melting Point | >230ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 334.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Resolution of liver fibrosis in chronic CCl4 administration in the rat after discontinuation of treatment: effect of silymarin, silibinin, colchicine and trimethylcolchicinic acid.
Basic Clin Pharmacol Toxicol. 96(5) , 375-80, (2005) The purpose of this work was to obtain a suitable model of fibrosis, in which spontaneous reversion was minimal, to study the ability of silymarin, silibinin, colchicine and trimethylcolchicinic acid (TMCA) to reverse it. Reversal of liver fibrosis was studie... |
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Effect of colchicine and trimethylcolchicinic acid on CCl4-induced cirrhosis in the rat.
Pharmacol. Toxicol. 79(5) , 241-6, (1996) Colchicine is one of the most promising drugs for the treatment of cirrhosis. However, due to its toxicity, other drugs are being evaluated and colchicine-like molecules may be good alternatives. The aim of this work was to compare the beneficial effects of c... |
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The role of microtubules in pinocytosis. Inhibition of fluid-phase pinocytosis in the rat visceral yolk sac by mitoclasic and related agents.
Cell Biol. Int. Rep. 7(8) , 593-602, (1983) Colchicine, demecolcine and vinblastine all effectively inhibited the pinocytic capture of 125I-labelled poly(vinylpyrrolidone) by rat visceral yolk sacs cultured in vitro. Complete inhibition did not occur until 2-3h after addition of mitoclasic agent and th... |
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Comparative study of colchicine and trimethylcolchicinic acid on prolonged bile duct obstruction in the rat.
J. Appl. Toxicol. 16(3) , 269-75, (1996) The aim of this work was to compare the effects of colchicine and trimethylcolchicinic acid (TMCA) on liver damage induced by bile duct ligation (BDL) for 2 months in male Wistar rats. Colchicine was evaluated at a dose of 10 micrograms rat-1 day-1, p.o. only... |
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Trimethylcolchicinic acid decreases liver fibrosis and cholestasis induced by prolonged biliary obstruction in the rat.
J. Appl. Toxicol. 17(3) , 145-51, (1997) Colchicine is effective in decreasing hepatic fibrosis. However, several toxic reactions have been reported after colchicine treatment which are attributed to its ability to bind tubulin. The aim of this work is to determine if trimethylcolchicinic acid, whic... |