IU1
Modify Date: 2024-01-03 21:20:41
IU1 structure
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Common Name | IU1 | ||
|---|---|---|---|---|
| CAS Number | 314245-33-5 | Molecular Weight | 300.371 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 437.0±45.0 °C at 760 mmHg | |
| Molecular Formula | C18H21FN2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 218.1±28.7 °C | |
| Symbol |
GHS05 |
Signal Word | Danger | |
Use of IU1IU1 is a special Usp14 inhibitor with IC50 of 4-5 μM. |
| Name | 1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone |
|---|---|
| Synonym | More Synonyms |
| Description | IU1 is a special Usp14 inhibitor with IC50 of 4-5 μM. |
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| Related Catalog | |
| Target |
IC50: 4-5 μM (Usp14)[1] |
| In Vitro | Usp14, a proteasome-associated deubiquitinating enzyme, can inhibit the degradation of ubiquitin-protein conjugates, in vivo and in vitro. IU1inhibits the catalytic activity of proteasome associated Usp14 in vitro. The IC50 of IU1 for Usp14 is 4-5 μM. IU1 binds specifically to the activated form of Usp14. IU1 can potentially inhibit Usp14 by preventing its docking on the proteasome, but direct tests of this scenario proved negative. Usp14 inhibition is rapidly established upon addition of IU1 and rapidly reversed upon its removal. IU1 also promotes degradation of Sic1, a CDK inhibitor from S. cerevisiae[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 437.0±45.0 °C at 760 mmHg |
| Molecular Formula | C18H21FN2O |
| Molecular Weight | 300.371 |
| Flash Point | 218.1±28.7 °C |
| Exact Mass | 300.163788 |
| PSA | 25.24000 |
| LogP | 4.07 |
| Appearance of Characters | off-white to light brown |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.585 |
| Storage condition | Store at +4°C |
| Water Solubility | DMSO: >10mg/mL |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Post-endocytotic Deubiquitination and Degradation of the Metabotropic γ-Aminobutyric Acid Receptor by the Ubiquitin-specific Protease 14.
J. Biol. Chem. 291 , 7156-70, (2016) Mechanisms controlling the metabotropic γ-aminobutyric acid receptor (GABAB) cell surface stability are still poorly understood. In contrast with many other G protein-coupled receptors (GPCR), it is n... |
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Ubiquitin-specific protease 14 modulates degradation of cellular prion protein.
Sci. Rep. 5 , 11028, (2015) Prion diseases are fatal neurodegenerative disorders characterized by the accumulation of prion protein (PrP(C)). To date, there is no effective treatment for the disease. The accumulated PrP, termed ... |
| Ethanone, 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)- |
| IU1 |
| F1142-1244 |
| 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone |
| Usp14 inhibitor |