DC Chemicals Limited
China
Product Name: IU1
Price: $550.0/100mg $950.0/250mg $1900.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

314245-33-5

314245-33-5 structure

314245-33-5 structure

Name: IU1
Chemical Name: 1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone
CAS Number: 314245-33-5
Molecular Formula: C₁₈H₂₁FN₂O
Molecular Weight: 300.371
Catalog: Biochemical Inhibitor Ubiquitin inhibitor DUB inhibitor
Create Date: 2016-06-18 21:03:45
Modify Date: 2024-01-03 21:20:41
IU1 is a special Usp14 inhibitor with IC50 of 4-5 μM.

Name	1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone
Synonyms	Ethanone, 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)- IU1 F1142-1244 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone Usp14 inhibitor

Description	IU1 is a special Usp14 inhibitor with IC50 of 4-5 μM.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase Research Areas >> Cardiovascular Disease
Target	IC50: 4-5 μM (Usp14)[1]
In Vitro	Usp14, a proteasome-associated deubiquitinating enzyme, can inhibit the degradation of ubiquitin-protein conjugates, in vivo and in vitro. IU1inhibits the catalytic activity of proteasome associated Usp14 in vitro. The IC50 of IU1 for Usp14 is 4-5 μM. IU1 binds specifically to the activated form of Usp14. IU1 can potentially inhibit Usp14 by preventing its docking on the proteasome, but direct tests of this scenario proved negative. Usp14 inhibition is rapidly established upon addition of IU1 and rapidly reversed upon its removal. IU1 also promotes degradation of Sic1, a CDK inhibitor from S. cerevisiae[1].
References	[1]. Lee BH, et al. Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature. 2010 Sep 9;467(7312):179-84.

Density	1.2±0.1 g/cm3
Boiling Point	437.0±45.0 °C at 760 mmHg
Molecular Formula	C₁₈H₂₁FN₂O
Molecular Weight	300.371
Flash Point	218.1±28.7 °C
Exact Mass	300.163788
PSA	25.24000
LogP	4.07
Appearance	off-white to light brown
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.585
Storage condition	Store at +4°C
Water Solubility	DMSO: >10mg/mL

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H318
Precautionary Statements	P280-P305 + P351 + P338
Hazard Codes	Xi
Risk Phrases	41
Safety Phrases	61
RIDADR	NONH for all modes of transport
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%