2307472-03-1

2307472-03-1 structure

Name: IU1-248
Chemical Name: IU1-248
CAS Number: 2307472-03-1
Molecular Formula: C₂₀H₂₃N₃O₂
Molecular Weight: 337.42
Catalog: Signaling Pathways Cell Cycle/DNA Damage Deubiquitinase
Create Date: 2021-09-11 17:44:14
Modify Date: 2024-01-10 16:33:26
IU1-248, a derivative of IU1, is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM.

Name	IU1-248

Description	IU1-248, a derivative of IU1, is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase
In Vitro	IU1-248 exhibits an IC50 value of 0.83 μM toward USP14, which is comparable to that of IU1-47 (IC50=0.68 μM) and 10-fold more potent than that of IU1 (IC50=12.25 μM)[1].
References	[1]. Yiwei Wang, et al. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res. 2018 Dec;28(12):1186-1194.