EGFR-IN-46
Modify Date: 2025-08-24 12:30:09
EGFR-IN-46 structure
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Common Name | EGFR-IN-46 | ||
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| CAS Number | 2764772-88-3 | Molecular Weight | 503.56 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H32F3N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of EGFR-IN-46EGFR-IN-46 is a potent EGFR and FAK dual inhibitor with IC50s of 20.17 nM, 14.25 nM, respectively. EGFR-IN-46 significantly inhibits the growth of cancer cells. EGFR-IN-46 induces cell apoptosis[1]. |
| Name | EGFR-IN-46 |
|---|
| Description | EGFR-IN-46 is a potent EGFR and FAK dual inhibitor with IC50s of 20.17 nM, 14.25 nM, respectively. EGFR-IN-46 significantly inhibits the growth of cancer cells. EGFR-IN-46 induces cell apoptosis[1]. |
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| Related Catalog | |
| Target |
EGFR:20.17 nM (IC50) FAK:14.25 nM (IC50) |
| In Vitro | EGFR-IN-46 (compound 6h) (0-100 µM; 24 h) inhibits the growth activity against DLD1, HCT-116 cells with IC50s of 1.79, 3.28 µM, respectively[1]. EGFR-IN-46 (3 µM; 24 h) induces cell apoptosis in DLD1 cells[1]. EGFR-IN-46 exhibits weak TOP1 (Topoisomerase I) poisoning effect (-/+)[1]. Cell Proliferation Assay[1] Cell Line: DLD1, HCT-116, MDMBA-231, MCF-7, Hela cells Concentration: 10 µM Incubation Time: 24 h Result: Showed excellent growth inhibition with the percent growth inhibition of 92.36%, 89.34%, 84.76%, 90.36%, 90.78% for DLD1, HCT-116, MDMBA-231, MCF-7, Hela cells, respectively. Apoptosis Analysis[1] Cell Line: DLD1 cells Concentration: 3 µM Incubation Time: 24 h Result: Increased the total percentage of apoptotic cells from 7% to 90.33%. |
| References |
| Molecular Formula | C27H32F3N3O3 |
|---|---|
| Molecular Weight | 503.56 |
| InChIKey | GTFSJMZEXMPUJA-UHFFFAOYSA-N |
| SMILES | COc1cc2nc(-c3ccc(C(F)(F)F)cc3)cc(OCCCNC3CCN(C)CC3)c2cc1OC |