EGFR-IN-27

Modify Date: 2025-08-27 11:28:20

EGFR-IN-27 Structure
EGFR-IN-27 structure
 Common Name EGFR-IN-27
CAS Number 2752328-62-2 Molecular Weight 655.77
Density N/A Boiling Point N/A
Molecular Formula C35H46N9O2P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of EGFR-IN-27


EGFR-IN-27 is a potent EGFR inhibitor with IC50s of <50 nM for EGFR Del, L858R, Del/T790M, L858R/T790M, Del/T790M/C797S, and L858R/T790M/C797S, respectively (WO2021249324A1, compound 511)[1].

 Names

Name EGFR-IN-27

 EGFR-IN-27 Biological Activity

Description EGFR-IN-27 is a potent EGFR inhibitor with IC50s of <50 nM for EGFR Del, L858R, Del/T790M, L858R/T790M, Del/T790M/C797S, and L858R/T790M/C797S, respectively (WO2021249324A1, compound 511)[1].
Related Catalog
Target

EGFRdel19:<50 nM (IC50)

EGFRL858R:<50 nM (IC50)

EGFRL858R/T790M:<50 nM (IC50)

EGFRdel19 T790M C797S:<50 nM (IC50)

EGFR (C797S/T790M/L858R):<50 nM (IC50)

EGFRdel19 T790M:<50 nM (IC50)

References

[1]. Alkenyl pyrimidine compound, preparation method therefor, and application thereof. WO2021249324A1.

 Chemical & Physical Properties

Molecular Formula C35H46N9O2P
Molecular Weight 655.77
InChIKey LUKWWQICCRFYBL-UHFFFAOYSA-N
SMILES C=Cc1cnc(Nc2cc(CC)c(N3CCC(N4CCN(C)CC4)CC3)cc2OC)nc1Nc1ccc2nccnc2c1P(C)(C)=O
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Chemsrc provides EGFR-IN-27(CAS#:2752328-62-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of EGFR-IN-27 are included as well.>> amp version: EGFR-IN-27

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