PI3K/Akt/mTOR-IN-2
Modify Date: 2025-08-25 13:54:41
PI3K/Akt/mTOR-IN-2 structure
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Common Name | PI3K/Akt/mTOR-IN-2 | ||
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| CAS Number | 2757804-89-8 | Molecular Weight | 285.29 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H13F2NO | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PI3K/Akt/mTOR-IN-2PI3K/Akt/mTOR-IN-2 is a PI3K/AKT/mTOR pathway inhibitor. PI3K/Akt/mTOR-IN-2 possess anti-cancer effects and selectivity against MDA-MB-231 cells with IC50 value of 2.29 μM. PI3K/Akt/mTOR-IN-2 can induce cancer cell cycle arrest and apoptosis[1]. |
| Name | PI3K/Akt/mTOR-IN-2 |
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| Description | PI3K/Akt/mTOR-IN-2 is a PI3K/AKT/mTOR pathway inhibitor. PI3K/Akt/mTOR-IN-2 possess anti-cancer effects and selectivity against MDA-MB-231 cells with IC50 value of 2.29 μM. PI3K/Akt/mTOR-IN-2 can induce cancer cell cycle arrest and apoptosis[1]. |
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| Related Catalog | |
| Target |
IC50: 2.29 μM (PI3K/AKT/mTOR) in MDA-MB-231[1] |
| In Vitro | PI3K/Akt/mTOR-IN-2 (compound 23) (0.5 - 100 μM; 72 hours) exhibits effective anti-cancer activity with IC50s of 2.29 - 24.63 μM, of which, IC50 in MDA-MB-231 is 2.29 μM[1]. PI3K/Akt/mTOR-IN-2 (1 μM, 2 μM and 4 μM; 24 hours) induces growth inhibition of MDA-MB-231 cells by cell cycle arrest at G0/G1[1]. PI3K/Akt/mTOR-IN-2 (1 μM, 2 μM and 4 μM; 24, 48 and 72 hours) induces apoptosis in MDA-MB-231 cells with both dose- and time-dependent manners[1]. PI3K/Akt/mTOR-IN-2 (1 μM, 2 μM and 4 μM; 48 hours) increases the expression of Bax, and decreases the expression of Bcl-2 in MDA-MB-231 cells[1]. PI3K/Akt/mTOR-IN-2 (1 μM, 2 μM and 4 μM; 24 hours) induces mitochondria-dependent apoptosis in MDA-MB-231 cells through disruption of MMP, accumulation of ROS, depletion of GSH and elevation of intracellular Ca2+[1]. Cell Proliferation Assay Cell Line: PC3, BGC-823, A549, MCF-7, MDA-MB-231 cells and MCF-10A cells[1] Concentration: 0.5 - 100 μM Incubation Time: 72 hours Result: Exhibited effective anti-cancer activity with IC50s of 2.29 - 24.63 μM, of which, IC50 in MDA-MB-231 was 2.29 μM. Cell Cycle Analysis Cell Line: MDA-MB-231[1] Concentration: 1 μM, 2 μM and 4 μM Incubation Time: 24 hours Result: Induced growth inhibition of MDA-MB-231 cells by cell cycle arrest at G0/G1. Apoptosis Analysis Cell Line: MDA-MB-231[1] Concentration: 1 μM, 2 μM and 4 μM Incubation Time: 24, 48 and 72 hours Result: Induced apoptosis in MDA-MB-231 cells with both dose- and time-dependent manners. Western Blot Analysis Cell Line: MDA-MB-231[1] Concentration: 1 μM, 2 μM and 4 μM Incubation Time: 48 hours Result: Increased the expression of Bax, and decreased the expression of Bcl-2 |
| References |
| Molecular Formula | C17H13F2NO |
|---|---|
| Molecular Weight | 285.29 |
| InChIKey | XBYJYKHTEFYLFX-UHFFFAOYSA-N |
| SMILES | Fc1cc(F)cc(C2OCCc3c2[nH]c2ccccc32)c1 |