2281803-33-4

2281803-33-4 structure

Name: MEK/PI3K-IN-2
Chemical Name: MEK/PI3K-IN-2
CAS Number: 2281803-33-4
Molecular Formula: C₃₈H₄₁F₅IN₉O₇
Molecular Weight: 957.68
Catalog: Signaling Pathways Cell Cycle/DNA Damage PERK
Create Date: 2022-06-28 15:06:39
Modify Date: 2024-01-10 12:48:25
MEK/PI3K-IN-2 (compound 6s) is a potent MEK/PI3K inhibitor, with IC50 values of 352 nM (MEK1), 107 nM (PI3Kα), and 137 nM (PI3Kδ), respectively. MEK/PI3K-IN-2 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-2 shows anti-proliferative activity against tumor cell lines[1].

Name	MEK/PI3K-IN-2

Description	MEK/PI3K-IN-2 (compound 6s) is a potent MEK/PI3K inhibitor, with IC50 values of 352 nM (MEK1), 107 nM (PI3Kα), and 137 nM (PI3Kδ), respectively. MEK/PI3K-IN-2 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-2 shows anti-proliferative activity against tumor cell lines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> MEK Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> Cell Cycle/DNA Damage >> PERK
Target	MEK1:352 ± 2 nM (IC50) PI3Kα:107 ± 21 nM (IC50) PI3Kδ:137 ± 7 nM (IC50) PI3Kγ:2567 ± 364 nM (IC50) PI3Kβ:3880 ± 725 nM (IC50)
References	[1]. Van Dort ME, et al. Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors. Eur J Med Chem. 2022 Feb 5;229:113996.

Molecular Formula	C₃₈H₄₁F₅IN₉O₇
Molecular Weight	957.68