2,2-Oxybis(ethylamine)

Modify Date: 2024-01-02 18:29:19

2,2-Oxybis(ethylamine) Structure
2,2-Oxybis(ethylamine) structure
Common Name 2,2-Oxybis(ethylamine)
CAS Number 2752-17-2 Molecular Weight 104.151
Density 1.0±0.1 g/cm3 Boiling Point 185.9±15.0 °C at 760 mmHg
Molecular Formula C4H12N2O Melting Point N/A
MSDS Chinese USA Flash Point 74.8±14.1 °C

 Use of 2,2-Oxybis(ethylamine)


22-Oxybis(ethylamine) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-(2-aminoethoxy)ethanamine
Synonym More Synonyms

 2,2-Oxybis(ethylamine) Biological Activity

Description 22-Oxybis(ethylamine) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 185.9±15.0 °C at 760 mmHg
Molecular Formula C4H12N2O
Molecular Weight 104.151
Flash Point 74.8±14.1 °C
Exact Mass 104.094963
PSA 61.27000
LogP -1.23
Vapour Pressure 0.7±0.4 mmHg at 25°C
Index of Refraction 1.455

 Safety Information

Hazard Codes C: Corrosive;
Risk Phrases R34
Safety Phrases 45-36/37/39-26
RIDADR 2735.0
Hazard Class 8.0
HS Code 2922199090

 Synthetic Route

 Customs

HS Code 2922199090
Summary 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

2,2'-Oxydiethanamine
GXVUZYLYWKWJIM-UHFFFAOYSA
diamino-PEG
EINECS 220-395-5
Ethanamine, 2,2'-oxybis-
2,2'-Oxydiethylamine
Bis(2-aminoethyl) Ether
2,2′-Oxybis(ethylamine)
2,2-Oxybis(ethylamine)
1,5-diamino-3-oxa-pentane
2,2'-Oxybis(ethylamine)
2,2‘-Oxybis(ethylamine)
2-(2-Aminoethoxy)ethylamine
2-aminoethyl ether
Ethanamine,2,2'-oxybis
2,2'-Diaminodiethyl Ether
2,2'-DITHIOBISBENZOIC ACID
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