2,2-Oxybis(ethylamine)

Names

[ Name ]:
2,2-Oxybis(ethylamine)

[Synonym ]:
2,2'-Oxydiethanamine
GXVUZYLYWKWJIM-UHFFFAOYSA
diamino-PEG
EINECS 220-395-5
Ethanamine, 2,2'-oxybis-
2,2'-Oxydiethylamine
Bis(2-aminoethyl) Ether
2,2′-Oxybis(ethylamine)
2,2-Oxybis(ethylamine)
1,5-diamino-3-oxa-pentane
2,2'-Oxybis(ethylamine)
2,2‘-Oxybis(ethylamine)
2-(2-Aminoethoxy)ethylamine
2-aminoethyl ether
Ethanamine,2,2'-oxybis
2,2'-Diaminodiethyl Ether
2,2'-DITHIOBISBENZOIC ACID

Biological Activity

[Description]:

22-Oxybis(ethylamine) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
185.9±15.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄H₁₂N₂O

[ Molecular Weight ]:
104.151

[ Flash Point ]:
74.8±14.1 °C

[ Exact Mass ]:
104.094963

[ PSA ]:
61.27000

[ LogP ]:
-1.23

[ Vapour Pressure ]:
0.7±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.455

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
C: Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
45-36/37/39-26

[ RIDADR ]:
2735.0

[ Hazard Class ]:
8.0

[ HS Code ]:
2922199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%