Azido-PEG1-azide

Names

[ Name ]:
Azido-PEG1-azide

[Synonym ]:
bisethyletherazide
1-azido-2 (2-azidoethoxy)-ethane
1-(2-azidoethoxy)-2-azidoethane
Ether,bis(2-azidoethyl) (7CI,8CI)
1,1'-Oxybis(2-azidoethane)
Ethane,1,1'-oxybis[2-azido
1,5-diazido-3-oxapentane
bis-(2-azido-ethyl) ether

Biological Activity

[Description]:

Azido-PEG1-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄H₈N₆O

[ Molecular Weight ]:
156.14600

[ Exact Mass ]:
156.07600

[ PSA ]:
108.73000

[ LogP ]:
0.52912

Safety Information

[ HS Code ]:
2929909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2929909090

[ Summary ]:
2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%