Ms-PEG2-Ms

Names

[ Name ]:
Ms-PEG2-Ms

[Synonym ]:
oxydiethane-2,1-diyl dimethanesulfonate
diethyleneglycol bis-methane-sulfonyl ester
dimethyl 3-oxapentane-1,5-disulfonate
di-mesyl-diglyme
Diethylene Glycol Dimesylate
2,2'-Oxybis-ethanol Dimethanesulfonate

Biological Activity

[Description]:

Ms-PEG2-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.389g/cm3

[ Boiling Point ]:
480.2ºC at 760 mmHg

[ Molecular Formula ]:
C₆H₁₄O₇S₂

[ Molecular Weight ]:
262.30100

[ Flash Point ]:
244.2ºC

[ Exact Mass ]:
262.01800

[ PSA ]:
112.73000

[ LogP ]:
1.11700

[ Index of Refraction ]:
1.47

Safety Information

[ Hazard Codes ]:
T+

[ HS Code ]:
2904100000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2904100000

[ Summary ]:
2904100000 derivatives containing only sulpho groups, their salts and ethyl esters。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%