Bis(chloroethyl) ether

Modify Date: 2024-01-02 18:37:33

Bis(chloroethyl) ether Structure
Bis(chloroethyl) ether structure
 Common Name Bis(chloroethyl) ether
CAS Number 111-44-4 Molecular Weight 143.012
Density 1.2±0.1 g/cm3 Boiling Point 178.7±0.0 °C at 760 mmHg
Molecular Formula C4H8Cl2O Melting Point −47 °C(lit.)
MSDS Chinese USA Flash Point 55.0±0.0 °C
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08		 Signal Word Danger

 Names

Name 2,2'-Dichlorodiethyl ether
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 178.7±0.0 °C at 760 mmHg
Melting Point −47 °C(lit.)
Molecular Formula C4H8Cl2O
Molecular Weight 143.012
Flash Point 55.0±0.0 °C
Exact Mass 141.995224
PSA 9.23000
LogP 1.19
Vapour Pressure 1.3±0.3 mmHg at 25°C
Index of Refraction 1.431
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility Slightly soluble. 1.72 g/100 mL

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KN0875000
CHEMICAL NAME :
Ether, bis(2-chloroethyl)
CAS REGISTRY NUMBER :
111-44-4
BEILSTEIN REFERENCE NO. :
0605317
LAST UPDATED :
199712
DATA ITEMS CITED :
57
MOLECULAR FORMULA :
C4-H8-Cl2-O
MOLECULAR WEIGHT :
143.02
WISWESSER LINE NOTATION :
G2O2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
330 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
209 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
650 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
126 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
90 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
500 ppm/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
112 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
33 gm/kg/79W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - lymphoma, including Hodgkin's disease
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2400 mg/kg/60W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TEST SYSTEM :
Insect - Drosophila melanogaster
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 23,51,1994 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 58 mg/m3 (10 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 29 mg/m3 (5 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,117,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,117,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW 85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971 Volume(issue)/page/year: 5,250,1970 TOXICOLOGY REVIEW BNYMAM Bulletin of the New York Academy of Medicine. (New York Academy of Medicine, 2 E. 103rd St., New York, NY 10029) Ser 2: V.1- 1925- Volume(issue)/page/year: 54,413,1978 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 ppm (30 mg/m3) (skin) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,16,1973 OSHA PEL (Gen Indu):CL 15 ppm (90 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):CL 15 ppm (90 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):CL 15 ppm (90 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):CL 15 ppm (90 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (30 mg/m3);STEL 10 ppm (60 mg/m3);Skin JAN 1993 OEL-AUSTRIA:TWA 10 ppm (60 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 5 ppm (29 mg/m3);STEL 10 ppm (58 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 5 ppm (30 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 5 ppm (30 mg/m3);STEL 10 ppm (60 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (30 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 10 ppm (60 mg/m3);Skin JAN 1993 OEL-JAPAN:TWA 15 ppm (88 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (30 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 15 ppm (90 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 10 mg/m3 JAN 1993 OEL-RUSSIA:STEL 0.6 mg/m3;Skin JAN 1993 OEL-RUSSIA:TWA 15 ppm;STEL 2 mg/m3;Skin JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (30 mg/m3);STEL 25 ppm (50 mg/m3);Skin JAN 1993 OEL-THAILAND:TWA 15 ppm (90 mg/m3) JAN 1993 OEL-TURKEY:TWA 15 ppm (90 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DICHLOROETHYLETHER-air:CA TWA 5 ppm (Sk);STEL 10 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84164 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 41 (estimated)

 Safety Information

Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger
Hazard Statements H225-H301 + H311 + H331-H370
Precautionary Statements P210-P260-P280-P301 + P310-P311
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T+:Verytoxic;
Risk Phrases R10;R26/27/28;R40
Safety Phrases S27-S28-S36/37-S45-S7/9-S28A
RIDADR UN 1916 6.1/PG 2
WGK Germany 2
RTECS KN0875000
Packaging Group II
Hazard Class 6.1
HS Code 29091900

 Synthetic Route

 Customs

HS Code 2909199090
Summary 2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

 Articles12

More Articles
Carcinogenicity tests of certain environmental and industrial chemicals.

J. Natl. Cancer Inst. 67(1) , 75-88, (1981)

Fourteen chemicals of varied uses were tested for carcinogenicity by oral administration in male and female Charles River CD rats. Under the conditions of the tests, propane sultone, propylene imine, ...
Thiodiglycolic acid: a major metabolite of bis(2-chloroethyl)ether.

Toxicol. Appl. Pharmacol. 47(1) , 23-34, (1979)

Male rats were given a single oral dose (40 mg/kg) of bis(2-chloroethyl)ether (BCEE). Less than 2% of the dose was recovered from the expired air as the unaltered parent compound during an 8-hr collec...
Bis(2-chloroethyl)ether.

IARC Monogr. Eval. Carcinog. Risks Hum. 71 Pt 3 , 1265-9, (1999)

 Synonyms

2,2'-Dichlorodiethyl Ether
ethane, 1-chloro-2-(2-chloroethoxy)-
MFCD00000975
Bis(2-Chloroethyl)ether
Bis(2-chloroethyl) ether
Ethane, 2,2'-oxybis[1-chloro-
EINECS 203-870-1
1-Chloro-2-(2-chloroethoxy)ethane
2-Chloroethyl ether
Bis(chloroethyl) ether
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