1H-Indazole

Modify Date: 2024-01-02 08:04:12

1H-Indazole structure	Common Name	1H-Indazole
	CAS Number	271-44-3	Molecular Weight	118.136
	Density	1.2±0.1 g/cm3	Boiling Point	270.0±9.0 °C at 760 mmHg
	Molecular Formula	C₇H₆N₂	Melting Point	145-148 °C(lit.)
	MSDS	N/A	Flash Point	128.5±11.7 °C

Use of 1H-Indazole

Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases[1][2][3][4][5].

Name	1H-indazole
Synonym	More Synonyms

Description	Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases[1][2][3][4][5].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Autophagy >> LRRK2 Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
In Vitro	Indazole compounds possess potential anticancer activity, and indazole-based agents such as, Axitinib (HY-10065), Lonidamine (HY-B0486) and Pazopanib (HY-10208) have already been used for cancer research, demonstrating indazole compounds as useful templates for the development of novel anticancer agents[1]. Indazoles show potent activities against neurological disorders by inhibiting the monoamine oxidase (MAO) and kinase enzymes like Glycogen synthase kinase 3 (GSK3), and leucinerich repeat kinase enzyme 2 (LRRK2)[2]. Various natural and synthetic indazole derivatives Nigellicine, Nigellamine, Nigellidine, Zanubrutinib (HY-101474A) and SCH772984 (HY-50846) showes prominent results to cure various gastrointestinal disorders[4].
References	[1]. Shang C, et al. The Anticancer Activity of Indazole Compounds: A Mini Review. Curr Top Med Chem. 2021;21(5):363-376. [2]. Pal D, et al. Importance of Indazole against Neurological Disorders. Curr Top Med Chem. 2022;22(14):1136-1151. [3]. Uppulapu SK, et al. Indazole and its Derivatives in Cardiovascular Diseases: Overview, Current Scenario, and Future Perspectives. Curr Top Med Chem. 2022;22(14):1177-1188. [4]. Saha S, et al. Indazole Derivatives Effective against Gastrointestinal Diseases. Curr Top Med Chem. 2022;22(14):1189-1214. [5]. Qin J, et al. Indazole as a Privileged Scaffold: The Derivatives and their Therapeutic Applications. Anticancer Agents Med Chem. 2021;21(7):839-860.

Density	1.2±0.1 g/cm3
Boiling Point	270.0±9.0 °C at 760 mmHg
Melting Point	145-148 °C(lit.)
Molecular Formula	C₇H₆N₂
Molecular Weight	118.136
Flash Point	128.5±11.7 °C
Exact Mass	118.053101
PSA	28.68000
LogP	1.82
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.697
Water Solubility	SOLUBLE IN HOT WATER

1H-Indazole MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NK7745000

CHEMICAL NAME :: 1H-Indazole

CAS REGISTRY NUMBER :: 271-44-3

LAST UPDATED :: 199501

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H6-N2

MOLECULAR WEIGHT :: 118.15

WISWESSER LINE NOTATION :: T56 BMNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 440 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,480,1963

Hazard Codes	Xi
Safety Phrases	S22-S24/25
WGK Germany	3
RTECS	NK7745000
HS Code	29339990

Precursor 10
CAS#:89-98-5 2-Chlorobenzaldehyde CAS#:73183-34-3 Bis(pinacolato)... CAS#:186407-74-9 4-Bromoindazole CAS#:88284-48-4 2-trimethylsily...
CAS#:18107-18-1 (Trimethylsilyl... CAS#:75307-67-4 2,2-dimethyl-5-... CAS#:446-52-6 2-Fluorobenzaldehyde CAS#:1437769-72-6 2-(4,4,5,5-tetr...
CAS#:679794-95-7 3-trimethylsily... CAS#:4403-69-4 2-AMINOBENZYLAMINE
DownStream 10
CAS#:326474-67-3 3-bromo-1-methy... CAS#:32829-25-7 INDAZOL-1-YL-AC... CAS#:3176-66-7 7-Methyl-1H-indazole CAS#:33334-08-6 1H-Indazol-1-amine
CAS#:33334-11-1 2H-Indazol-2-amine CAS#:36760-20-0 3,5-Dichloro-1H... CAS#:29110-74-5 3-Chloro-1H-indazole CAS#:142801-06-7 (3-methylindazo...
CAS#:40598-94-5 3-Bromo-1H-indazole CAS#:40598-76-3 3,5-dibromo-1H-...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

isoindazole

Indazole

1H-Indazole

indazole-

MFCD00005691

EINECS 205-978-4

1,2-Benzopyrazole

1h-indazol

1,2-Benzodiazole

BENZOPYRAZOLE

Indazol

2-Azaindole

benzodiazole

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 1H-Indazole
Price: ￥338.0/5g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Indazole
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Indazole
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Indazole
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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