Boc-NH-PEG1-OH

Modify Date: 2024-01-02 19:03:39

Boc-NH-PEG1-OH Structure
Boc-NH-PEG1-OH structure
 Common Name Boc-NH-PEG1-OH
CAS Number 26690-80-2 Molecular Weight 161.199
Density 1.0±0.1 g/cm3 Boiling Point 267.2±23.0 °C at 760 mmHg
Molecular Formula C7H15NO3 Melting Point N/A
MSDS Chinese USA Flash Point 115.4±22.6 °C
Symbol GHS05 GHS06
GHS05, GHS06		 Signal Word Danger

 Use of Boc-NH-PEG1-OH


Boc-NH-PEG1-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name tert-butyl n-(2-hydroxyethyl)carbamate
Synonym More Synonyms

 Boc-NH-PEG1-OH Biological Activity

Description Boc-NH-PEG1-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs
In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 267.2±23.0 °C at 760 mmHg
Molecular Formula C7H15NO3
Molecular Weight 161.199
Flash Point 115.4±22.6 °C
Exact Mass 161.105194
PSA 58.56000
LogP 0.49
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.450
Storage condition 2-8°C

 Safety Information

Symbol GHS05 GHS06
GHS05, GHS06
Signal Word Danger
Hazard Statements H301-H315-H318-H335
Precautionary Statements P261-P280-P301 + P310-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T:Toxic;
Risk Phrases R25;R37/38;R41
Safety Phrases S26-S39-S45-S36/37/39
RIDADR UN 2810 6.1/PG 3
WGK Germany 3
Hazard Class 6.1
HS Code 2924199090

 Synthetic Route

 Customs

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles2

More Articles

Synthesis , 133, (1993)

Synth. Commun. 21 , 359, (1991)

 Synonyms

tert-Butyl (2-hydroxyethyl)carbamate
(2-hydroxyethyl)carbamic acid t-butyl ester
Boc-NH-(CH2)2-1-naphthylamide
boc-ethanolamine
Boc-2-aminoethanol
2-Boc-ethanolamine
2-(tert-Butoxycarbonyl)ethanolamine
2-(tert-ButoxycarbonylaMino)-1-ethanol
(2-hydroxy-ethyl)-carbamic acid tert-butyl ester
Carbamic acid, N-(2-hydroxyethyl)-, 1,1-dimethylethyl ester
MFCD00056657
N-(t-butoxycarbonyl)-2-hydroxy-ethylamine
N-(tert-Butoxycarbonyl)ethanolamine
2-(Boc-amino)-1-ethanol
N-(2-Hydroxyethyl)carbamic Acid tert-Butyl Ester
boc-aminoethanol
Boc-Gly-ol
Boc-glycinol
2-Methyl-2-propanyl (2-hydroxyethyl)carbamate
N-Boc-ethanolamine
tert-Butyl N-(2-Hydroxyethyl)carbamate
2-(tert-butoxycarbonylamino)ethanol
tert-butyl N-(2-hydroxyethyl)-carbamate
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