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1347750-78-0

1347750-78-0 structure
1347750-78-0 structure
  • Name: Boc-NH-PEG5-CH2CH2COOH
  • Chemical Name: 2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azatricosan-23-oic acid
  • CAS Number: 1347750-78-0
  • Molecular Formula: C18H35NO9
  • Molecular Weight: 409.472
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-07-19 06:47:12
  • Modify Date: 2024-01-23 11:57:16
  • Boc-NH-PEG5-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].

Name 2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azatricosan-23-oic acid
Synonyms 2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azatricosan-23-oic acid
3,8,11,14,17,20-Hexaoxa-5-azatricosan-23-oic acid, 2,2-dimethyl-4-oxo-
Boc-N-amido-PEG5-acid
BOC-PEG5-CH2CH2COOH
t-Boc-N-amido-PEG5-acid
Description Boc-NH-PEG5-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Nathanael Gray, et al. Bifunctional compounds for her3 degradation and methods of use. WO2017117474A1.

Density 1.1±0.1 g/cm3
Boiling Point 536.9±50.0 °C at 760 mmHg
Molecular Formula C18H35NO9
Molecular Weight 409.472
Flash Point 278.5±30.1 °C
Exact Mass 409.231171
LogP -0.50
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.467