CISAPRIDEMONOHYDRATE
CISAPRIDEMONOHYDRATE structure
|
Common Name | CISAPRIDEMONOHYDRATE | ||
|---|---|---|---|---|
| CAS Number | 260779-88-2 | Molecular Weight | 483.96 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H31ClFN3O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS05 |
Signal Word | Danger | |
Use of CISAPRIDEMONOHYDRATECisapride monohydrate is an orally and potent 5-HT4 receptor agonist and hERG inhibitor. Cisapride monohydrate is an prokinetic agent which facilitates or restores motility throughout the length of the gastrointestinal tract. Cisapride monohydrate stimulates gastrointestinal motor activity through an indirect mechanism involving the release of acetylcholine mediated by postganglionic nerve endings in the myenteric plexus of the gut[1][2]. |
| Name | VZV0A4I38W |
|---|---|
| Synonym | More Synonyms |
| Description | Cisapride monohydrate is an orally and potent 5-HT4 receptor agonist and hERG inhibitor. Cisapride monohydrate is an prokinetic agent which facilitates or restores motility throughout the length of the gastrointestinal tract. Cisapride monohydrate stimulates gastrointestinal motor activity through an indirect mechanism involving the release of acetylcholine mediated by postganglionic nerve endings in the myenteric plexus of the gut[1][2]. |
|---|---|
| Related Catalog | |
| Target |
5-HT4 Receptor:0.14 μM (EC50) |
| References |
[1]. Wiseman, L.R., Faulds, D. Cisapride. Drugs 47, 116–152 (1994). |
| Molecular Formula | C23H31ClFN3O5 |
|---|---|
| Molecular Weight | 483.96 |
| InChIKey | QBYYXIDJOFZORM-UHFFFAOYSA-N |
| SMILES | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC.O |
| Storage condition | -20℃ |
| Symbol |
GHS05 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H318 |
| Precautionary Statements | P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| RIDADR | NONH for all modes of transport |
| RTECS | CU9372000 |
|
Acute cardiotoxicity evaluation of the marine biotoxins OA, DTX-1 and YTX.
Toxins (Basel.) 7 , 1030-47, (2015) Phycotoxins are marine toxins produced by phytoplankton that can get accumulated in filter feeding shellfish. Human intoxication episodes occur due to contaminated seafood consumption. Okadaic acid (O... |
|
|
High-Content Assay Multiplexing for Toxicity Screening in Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Hepatocytes.
Assay Drug Dev. Technol. 13 , 529-46, (2015) Cell-based high-content screening (HCS) assays have become an increasingly attractive alternative to traditional in vitro and in vivo testing in pharmaceutical drug development and toxicological safet... |
|
|
A pharmacologically validated, high-capacity, functional thallium flux assay for the human Ether-à-go-go related gene potassium channel.
Assay Drug Dev. Technol. 8 , 714-26, (2010) The voltage-gated potassium channel, human Ether-à-go-go related gene (hERG), represents the molecular component of IKr, one of the potassium currents involved in cardiac action potential repolarizati... |
| CISAPRIDE MONOHYDRATE |
| UNII:VZV0A4I38W |
| Benzamide, 4-amino-5-chloro-N-[(3S,4R)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-, hydrate (1:1) |
| 4-Amino-5-chloro-N-{(3S,4R)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl}-2-methoxybenzamide hydrate (1:1) |
| VZV0A4I38W |