260779-88-2

260779-88-2 structure

Name: CISAPRIDEMONOHYDRATE
Chemical Name: VZV0A4I38W
CAS Number: 260779-88-2
Molecular Formula: C₂₃H₃₁ClFN₃O₅
Molecular Weight: 483.96
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-07-10 17:12:24
Modify Date: 2024-01-09 14:24:25
Cisapride monohydrate is an orally and potent 5-HT4 receptor agonist and hERG inhibitor. Cisapride monohydrate is an prokinetic agent which facilitates or restores motility throughout the length of the gastrointestinal tract. Cisapride monohydrate stimulates gastrointestinal motor activity through an indirect mechanism involving the release of acetylcholine mediated by postganglionic nerve endings in the myenteric plexus of the gut[1][2].

Name	VZV0A4I38W
Synonyms	CISAPRIDE MONOHYDRATE UNII:VZV0A4I38W Benzamide, 4-amino-5-chloro-N-[(3S,4R)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-, hydrate (1:1) 4-Amino-5-chloro-N-{(3S,4R)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl}-2-methoxybenzamide hydrate (1:1) VZV0A4I38W

Description	Cisapride monohydrate is an orally and potent 5-HT4 receptor agonist and hERG inhibitor. Cisapride monohydrate is an prokinetic agent which facilitates or restores motility throughout the length of the gastrointestinal tract. Cisapride monohydrate stimulates gastrointestinal motor activity through an indirect mechanism involving the release of acetylcholine mediated by postganglionic nerve endings in the myenteric plexus of the gut[1][2].
Related Catalog	Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT4 Receptor:0.14 μM (EC50)
References	[1]. Wiseman, L.R., Faulds, D. Cisapride. Drugs 47, 116–152 (1994). [2]. Toga T, et al. The 5-HT(4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go-related gene (hERG)-blocking activities. J Pharmacol Sci. 2007 Oct;105(2):207-10.

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H318
Precautionary Statements	P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
RIDADR	NONH for all modes of transport
RTECS	CU9372000