CISAPRIDEMONOHYDRATE

Names

[ Name ]:
CISAPRIDEMONOHYDRATE

[Synonym ]:
CISAPRIDE MONOHYDRATE
UNII:VZV0A4I38W
Benzamide, 4-amino-5-chloro-N-[(3S,4R)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-, hydrate (1:1)
4-Amino-5-chloro-N-{(3S,4R)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl}-2-methoxybenzamide hydrate (1:1)
VZV0A4I38W

Biological Activity

[Description]:

Cisapride monohydrate is an orally and potent 5-HT4 receptor agonist and hERG inhibitor. Cisapride monohydrate is an prokinetic agent which facilitates or restores motility throughout the length of the gastrointestinal tract. Cisapride monohydrate stimulates gastrointestinal motor activity through an indirect mechanism involving the release of acetylcholine mediated by postganglionic nerve endings in the myenteric plexus of the gut[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT4 Receptor:0.14 μM (EC50)

[References]

[1]. Wiseman, L.R., Faulds, D. Cisapride. Drugs 47, 116–152 (1994).

[2]. Toga T, et al. The 5-HT(4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go-related gene (hERG)-blocking activities. J Pharmacol Sci. 2007 Oct;105(2):207-10.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₃₁ClFN₃O₅

[ Molecular Weight ]:
483.96

[ Storage condition ]:
-20℃

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
CU9372000

Articles

Acute cardiotoxicity evaluation of the marine biotoxins OA, DTX-1 and YTX.

Toxins (Basel.) 7 , 1030-47, (2015)

Phycotoxins are marine toxins produced by phytoplankton that can get accumulated in filter feeding shellfish. Human intoxication episodes occur due to contaminated seafood consumption. Okadaic acid (O...

High-Content Assay Multiplexing for Toxicity Screening in Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Hepatocytes.

Assay Drug Dev. Technol. 13 , 529-46, (2015)

Cell-based high-content screening (HCS) assays have become an increasingly attractive alternative to traditional in vitro and in vivo testing in pharmaceutical drug development and toxicological safet...

A pharmacologically validated, high-capacity, functional thallium flux assay for the human Ether-à-go-go related gene potassium channel.

Assay Drug Dev. Technol. 8 , 714-26, (2010)

The voltage-gated potassium channel, human Ether-à-go-go related gene (hERG), represents the molecular component of IKr, one of the potassium currents involved in cardiac action potential repolarizati...

Related Compounds

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