Wiskostatin
Modify Date: 2024-01-24 12:50:46
Wiskostatin structure
|
Common Name | Wiskostatin | ||
|---|---|---|---|---|
| CAS Number | 253449-04-6 | Molecular Weight | 426.146 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 320.2±22.0 °C at 760 mmHg | |
| Molecular Formula | C17H18Br2N2O | Melting Point | 153-155ºC | |
| MSDS | Chinese USA | Flash Point | 147.4±22.3 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of WiskostatinWiskostatin is a potent and selective inhibitor of neuronal Wiskott-Aldrich syndrome protein (N-WASP)-mediated actin polymerization. Wiskostatin causes a rapid, profound, and irreversible decrease in cellular ATP levels[1]. |
| Name | 1-(3,6-dibromocarbazol-9-yl)-3-(dimethylamino)propan-2-ol |
|---|---|
| Synonym | More Synonyms |
| Description | Wiskostatin is a potent and selective inhibitor of neuronal Wiskott-Aldrich syndrome protein (N-WASP)-mediated actin polymerization. Wiskostatin causes a rapid, profound, and irreversible decrease in cellular ATP levels[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 320.2±22.0 °C at 760 mmHg |
| Melting Point | 153-155ºC |
| Molecular Formula | C17H18Br2N2O |
| Molecular Weight | 426.146 |
| Flash Point | 147.4±22.3 °C |
| Exact Mass | 423.978577 |
| PSA | 28.40000 |
| LogP | 5.65 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.657 |
| Storage condition | 2-8°C |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H413 |
| Precautionary Statements | P301 + P310 |
| Hazard Codes | Xi: Irritant;C: Corrosive; |
| RIDADR | UN3259 |
| HS Code | 2933990090 |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|
Claudin-5 is involved in breast cancer cell motility through the N-WASP and ROCK signalling pathways.
J. Exp. Clin. Cancer Res 31 , 43, (2012) Recent studies have shown dysregulation in TJ structure of several cancers including breast. Claudin-5 is a protein member of the TJ structure expressed in both endothelial and epithelial cells. This ... |
|
|
N-wasp is essential for the negative regulation of B cell receptor signaling.
PLoS Biol. 11 , e1001704, (2013) Negative regulation of receptor signaling is essential for controlling cell activation and differentiation. In B-lymphocytes, the down-regulation of B-cell antigen receptor (BCR) signaling is critical... |
|
|
Coordinated oscillations in cortical actin and Ca2+ correlate with cycles of vesicle secretion.
Nat. Cell Biol. 14 , 1261-9, (2012) The actin cortex both facilitates and hinders the exocytosis of secretory granules. How cells consolidate these two opposing roles was not well understood. Here we show that antigen activation of mast... |
| 1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(dimethylamino)-2-propanol |
| 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(dimethylamino)propan-2-ol |
| 1-(3,6-Dibromo-carbazol-9-yl)-3-dimethylamino-propan-2-ol |
| 1-(3,6-dibromocarbazol-9-yl)-3-dimethylaminopropan-2-ol |
| Wiskostatin |
| 1-(3,6-dibromocarbazol-9-yl)-3-(dimethylamino)propan-2-ol |
| 9H-Carbazole-9-ethanol, 3,6-dibromo-α-[(dimethylamino)methyl]- |