Wiskostatin

Names

[ Name ]:
Wiskostatin

[Synonym ]:
1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(dimethylamino)-2-propanol
1-(3,6-dibromo-9H-carbazol-9-yl)-3-(dimethylamino)propan-2-ol
1-(3,6-Dibromo-carbazol-9-yl)-3-dimethylamino-propan-2-ol
1-(3,6-dibromocarbazol-9-yl)-3-dimethylaminopropan-2-ol
Wiskostatin
1-(3,6-dibromocarbazol-9-yl)-3-(dimethylamino)propan-2-ol
9H-Carbazole-9-ethanol, 3,6-dibromo-α-[(dimethylamino)methyl]-

Biological Activity

[Description]:

Wiskostatin is a potent and selective inhibitor of neuronal Wiskott-Aldrich syndrome protein (N-WASP)-mediated actin polymerization. Wiskostatin causes a rapid, profound, and irreversible decrease in cellular ATP levels[1].

[Related Catalog]:

Signaling Pathways >> Cytoskeleton >> Arp2/3 Complex

Research Areas >> Neurological Disease

[References]

[1]. Guerriero CJ, et al. N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels. Am J Physiol Cell Physiol. 2007;292(4):C1562-C1566.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
320.2±22.0 °C at 760 mmHg

[ Melting Point ]:
153-155ºC

[ Molecular Formula ]:
C₁₇H₁₈Br₂N₂O

[ Molecular Weight ]:
426.146

[ Flash Point ]:
147.4±22.3 °C

[ Exact Mass ]:
423.978577

[ PSA ]:
28.40000

[ LogP ]:
5.65

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.657

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H413

[ Precautionary Statements ]:
P301 + P310

[ Hazard Codes ]:
Xi: Irritant;C: Corrosive;

[ RIDADR ]:
UN3259

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Claudin-5 is involved in breast cancer cell motility through the N-WASP and ROCK signalling pathways.

J. Exp. Clin. Cancer Res 31 , 43, (2012)

Recent studies have shown dysregulation in TJ structure of several cancers including breast. Claudin-5 is a protein member of the TJ structure expressed in both endothelial and epithelial cells. This ...

N-wasp is essential for the negative regulation of B cell receptor signaling.

PLoS Biol. 11 , e1001704, (2013)

Negative regulation of receptor signaling is essential for controlling cell activation and differentiation. In B-lymphocytes, the down-regulation of B-cell antigen receptor (BCR) signaling is critical...

Coordinated oscillations in cortical actin and Ca2+ correlate with cycles of vesicle secretion.

Nat. Cell Biol. 14 , 1261-9, (2012)

The actin cortex both facilitates and hinders the exocytosis of secretory granules. How cells consolidate these two opposing roles was not well understood. Here we show that antigen activation of mast...