PROTAC IDO1 Degrader-1
Modify Date: 2023-01-24 15:59:57
PROTAC IDO1 Degrader-1 structure
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Common Name | PROTAC IDO1 Degrader-1 | ||
|---|---|---|---|---|
| CAS Number | 2488851-89-2 | Molecular Weight | 966.8 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C40H53BrFN9O13 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PROTAC IDO1 Degrader-1PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells. |
| Name | PROTAC IDO1 Degrader-1 |
|---|
| Description | PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells. |
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| Molecular Formula | C40H53BrFN9O13 |
|---|---|
| Molecular Weight | 966.8 |
| Storage condition | -20°C |