PROTAC IDO1 Degrader-1

Names

[ Name ]:
PROTAC IDO1 Degrader-1

Biological Activity

[Description]:

PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₀H₅₃BrFN₉O₁₃

[ Molecular Weight ]:
966.8

[ Storage condition ]:
-20°C

Related Compounds

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