2488851-89-2
2488851-89-2 structure
- Name: PROTAC IDO1 Degrader-1
- Chemical Name: PROTAC IDO1 Degrader-1
- CAS Number: 2488851-89-2
- Molecular Formula: C40H53BrFN9O13
- Molecular Weight: 966.8
- Create Date: 2021-09-14 17:42:48
- Modify Date: 2025-10-09 07:30:09
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PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells.
| Name | PROTAC IDO1 Degrader-1 |
|---|
| Description | PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells. |
|---|
| Molecular Formula | C40H53BrFN9O13 |
|---|---|
| Molecular Weight | 966.8 |
| Storage condition | -20°C |