Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PROTAC BET Degrader-1
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: PROTAC BET Degrader-1
Price: $Inquiry/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

2093386-22-0

2093386-22-0 structure

2093386-22-0 structure

Name: PROTAC BET Degrader-1
Chemical Name: PROTAC 11
CAS Number: 2093386-22-0
Molecular Formula: C₄₄H₄₅N₁₁O₉
Molecular Weight: 871.9
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2018-09-07 22:09:05
Modify Date: 2025-08-24 18:10:12
PROTAC BET Degrader-1 is a potent BET degrader based on PROTAC, decreasing BRD2, BRD3, and BRD4 protein levels at low concentration.

Name	PROTAC 11

Description	PROTAC BET Degrader-1 is a potent BET degrader based on PROTAC, decreasing BRD2, BRD3, and BRD4 protein levels at low concentration.
Related Catalog	Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain Signaling Pathways >> PROTAC >> PROTAC Research Areas >> Cancer
Target	BET[1]
In Vitro	PROTAC BET Degrader-1 (Compound 9) is a potent BET degrader based on PROTAC, decreases the level of BRD2, BRD3, and BRD4 proteins in RS4;11 cells at 3-10 nM, and inhibits the growth of this cell line with an IC50 of 4.3 nM, and 45.5 nM for MOLM-13 cells[1].
References	[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.

Molecular Formula	C₄₄H₄₅N₁₁O₉
Molecular Weight	871.9

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