PROTAC BET Degrader-1
Modify Date: 2025-08-24 18:10:12
PROTAC BET Degrader-1 structure
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Common Name | PROTAC BET Degrader-1 | ||
|---|---|---|---|---|
| CAS Number | 2093386-22-0 | Molecular Weight | 871.9 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C44H45N11O9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PROTAC BET Degrader-1PROTAC BET Degrader-1 is a potent BET degrader based on PROTAC, decreasing BRD2, BRD3, and BRD4 protein levels at low concentration. |
| Name | PROTAC 11 |
|---|
| Description | PROTAC BET Degrader-1 is a potent BET degrader based on PROTAC, decreasing BRD2, BRD3, and BRD4 protein levels at low concentration. |
|---|---|
| Related Catalog | |
| Target |
BET[1] |
| In Vitro | PROTAC BET Degrader-1 (Compound 9) is a potent BET degrader based on PROTAC, decreases the level of BRD2, BRD3, and BRD4 proteins in RS4;11 cells at 3-10 nM, and inhibits the growth of this cell line with an IC50 of 4.3 nM, and 45.5 nM for MOLM-13 cells[1]. |
| References |
| Molecular Formula | C44H45N11O9 |
|---|---|
| Molecular Weight | 871.9 |
| InChIKey | TXLUZGFDBDQACL-UHFFFAOYSA-N |
| SMILES | CCn1nc(C2CC2)cc1Nc1nc(C(=O)NCCCCNC(=O)COc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12 |