TC-2559 difumarate
Modify Date: 2025-08-26 19:02:19
TC-2559 difumarate structure
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Common Name | TC-2559 difumarate | ||
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| CAS Number | 2454492-41-0 | Molecular Weight | 438.43 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H26N2O9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TC-2559 difumarateTC-2559 idifumarate is a CNS-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist (EC50=0.18 μM). TC-2559 difumarate shows selectivity for α4β2 over α2β4, α4β4 and α3β4 receptors, with EC50s in the range of 10-30 µM. Antinociceptive effect[1][2]. |
| Name | TC-2559 difumarate |
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| Description | TC-2559 idifumarate is a CNS-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist (EC50=0.18 μM). TC-2559 difumarate shows selectivity for α4β2 over α2β4, α4β4 and α3β4 receptors, with EC50s in the range of 10-30 µM. Antinociceptive effect[1][2]. |
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| Related Catalog | |
| In Vivo | TC-2559 difumarate (1-10 mg/kg; i.p.) dose dependently reduces acute formalin-induced biphasic nociceptive responses in mice[2]. TC-2559 difumarate (0.3-3 mg/kg; i.p.) dose dependently inhibits CCI-induced neuropathic pain in rats[2]. Animal Model: Adult male mice (body weight 15-30 g) (formalin test)[2] Dosage: 1, 3, 10 mg/kg Administration: I.p. Result: Dose dependently reduced both early and late phases of formalin induced nociceptive behavioral responses. Animal Model: Adult male SD rats (body weight 200-220 g) (chronic constriction injury (CCI))[2] Dosage: 0.3, 1, 3 mg/kg Administration: I.p. Result: Significantly reversed CCI induced the paw withdrawal threshold decreases. |
| References |
| Molecular Formula | C20H26N2O9 |
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| Molecular Weight | 438.43 |