TC-2559 difumarate

Modify Date: 2024-01-11 09:23:13

TC-2559 difumarate structure	Common Name	TC-2559 difumarate
	CAS Number	2454492-41-0	Molecular Weight	438.43
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₆N₂O₉	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TC-2559 difumarate

TC-2559 idifumarate is a CNS-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist (EC50=0.18 μM). TC-2559 difumarate shows selectivity for α4β2 over α2β4, α4β4 and α3β4 receptors, with EC50s in the range of 10-30 µM. Antinociceptive effect[1][2].

Name	TC-2559 difumarate

Description	TC-2559 idifumarate is a CNS-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist (EC50=0.18 μM). TC-2559 difumarate shows selectivity for α4β2 over α2β4, α4β4 and α3β4 receptors, with EC50s in the range of 10-30 µM. Antinociceptive effect[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
In Vivo	TC-2559 difumarate (1-10 mg/kg; i.p.) dose dependently reduces acute formalin-induced biphasic nociceptive responses in mice[2]. TC-2559 difumarate (0.3-3 mg/kg; i.p.) dose dependently inhibits CCI-induced neuropathic pain in rats[2]. Animal Model: Adult male mice (body weight 15-30 g) (formalin test)[2] Dosage: 1, 3, 10 mg/kg Administration: I.p. Result: Dose dependently reduced both early and late phases of formalin induced nociceptive behavioral responses. Animal Model: Adult male SD rats (body weight 200-220 g) (chronic constriction injury (CCI))[2] Dosage: 0.3, 1, 3 mg/kg Administration: I.p. Result: Significantly reversed CCI induced the paw withdrawal threshold decreases.
References	[1]. Bencherif M, et al. TC-2559: a novel orally active ligand selective at neuronal acetylcholine receptors. Eur J Pharmacol. 2000;409(1):45-55. [2]. Cheng LZ, et al. Enhanced inhibitory synaptic transmission in the spinal dorsal horn mediates antinociceptive effects of TC-2559. Mol Pain. 2011;7:56. Published 2011 Aug 4.

Molecular Formula	C₂₀H₂₆N₂O₉
Molecular Weight	438.43

DC Chemicals Limited
China
Product Name: TC-2559 difumarate
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

TC-2559 difumarate suppliers

TC-2559 difumarate price

TC-2559 difumarate

Use of TC-2559 difumarate

Names

TC-2559 difumarate Biological Activity

Chemical & Physical Properties