TC-H 106

Modify Date: 2024-01-02 21:15:07

TC-H 106 structure	Common Name	TC-H 106
	CAS Number	937039-45-7	Molecular Weight	339.431
	Density	1.2±0.1 g/cm3	Boiling Point	627.3±45.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₅N₃O₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	333.1±28.7 °C

Use of TC-H 106

Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (HDAC 1, 2, and 3, with IC50 values of 150 nM , 760nM, and 370 nM, respectively), demonstrating no activity against class II HDACs.IC50 value: 150 nM (HDAC1), 370 nM (HDAC3), 760nM(HDAC2)Target: HDAC in vitro: Pimelic diphenylamide 106 has preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1.Pimelic diphenylamide 106 exhibits weaker inhibitory activities against HDAC 8 with IC50 of 5 μM after a 3-h preincubation with HDAC8.

Name	N'-(2-aminophenyl)-N-(4-methylphenyl)heptanediamide
Synonym	More Synonyms

Description	Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (HDAC 1, 2, and 3, with IC50 values of 150 nM , 760nM, and 370 nM, respectively), demonstrating no activity against class II HDACs.IC50 value: 150 nM (HDAC1), 370 nM (HDAC3), 760nM(HDAC2)Target: HDAC in vitro: Pimelic diphenylamide 106 has preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1.Pimelic diphenylamide 106 exhibits weaker inhibitory activities against HDAC 8 with IC50 of 5 μM after a 3-h preincubation with HDAC8.
Related Catalog	Research Areas >> Cancer
Target	HDAC1:150 nM (IC50) HDAC3:370 nM (IC50) HDAC2:760 nM (IC50) HDAC8:5000 nM (IC50)
References	[1]. Chou CJ, et al. Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J Biol Chem. 2008 Dec 19;283(51):35402-35409. [2]. Xu C, et al. Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing. Chem Biol. 2009 Sep 25;16(9):980-989.

Density	1.2±0.1 g/cm3
Boiling Point	627.3±45.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₅N₃O₂
Molecular Weight	339.431
Flash Point	333.1±28.7 °C
Exact Mass	339.194672
PSA	84.22000
LogP	2.51
Appearance of Characters	white solid
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.636
Storage condition	-20℃

TC-H 106 MSDS(Chinese)

RIDADR	NONH for all modes of transport

Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).

Bioorg. Med. Chem. 23 , 5151-5, (2015)

Two of the histone deacetylases, TbDAC1 and TbDAC3, have been reported to be essential genes in trypanosomes. Therefore, we tested the activity of a panel of human histone deacetylase inhibitors (HDAC...

Inhibition of Histone Deacetylases Permits Lipopolysaccharide-Mediated Secretion of Bioactive IL-1β via a Caspase-1-Independent Mechanism.

J. Immunol. 195 , 5421-31, (2015)

Histone deacetylase (HDAC) inhibitors (HDACi) are clinically approved anticancer drugs that have important immune-modulatory properties. We report the surprising finding that HDACi promote LPS-induced...

N-(2-Aminophenyl)-N'-(4-methylphenyl)heptanediamide

Pimelic Diphenylamide

Heptanediamide, N-(2-aminophenyl)-N-(4-methylphenyl)-

Pimelic Diphenylamide 106

TC-H 106

DC Chemicals Limited
China
Product Name: Pimelic Diphenylamide 106
Price: $450.0/100mg $900.0/250mg $1700.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

TC-H 106 suppliers

Price: $79/10mM*1mLinDMSO

Reference only. check more TC-H 106 price

TC-H 106

Use of TC-H 106

Names

TC-H 106 Biological Activity

Chemical & Physical Properties

MSDS

Safety Information

Articles2

Synonyms