1082739-92-1

1082739-92-1 structure

Name: TC-S 7005
Chemical Name: TC-S 7005
CAS Number: 1082739-92-1
Molecular Formula: C₂₁H₁₇N₃O₃
Molecular Weight: 359.38
Catalog: Signaling Pathways Cell Cycle/DNA Damage Polo-like Kinase (PLK)
Create Date: 2019-06-01 19:45:19
Modify Date: 2025-09-11 12:53:47
TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively[1].

Name	TC-S 7005

Description	TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Polo-like Kinase (PLK)
Target	PLK2:4 nM (IC50) PLK3:24 nM (IC50) PLK1:214 nM (IC50)
References	[1]. Hanan EJ, et al. Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5186-9.