TC-S 7006

Modify Date: 2025-09-11 20:46:53

TC-S 7006 Structure
TC-S 7006 structure
Common Name TC-S 7006
CAS Number 871307-18-5 Molecular Weight 404.82700
Density N/A Boiling Point N/A
Molecular Formula C21H14ClFN6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TC-S 7006


Tpl2 Kinase Inhibitor 1 (Compound 1) is a potent and selective Tpl2 (COT kinase, MAP3K8) inhibitor, plays an important role in the regulation of the inflammatory response and the progression of some cancers[1].

 Names

Name 4-(3-chloro-4-fluoroanilino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile
Synonym More Synonyms

 TC-S 7006 Biological Activity

Description Tpl2 Kinase Inhibitor 1 (Compound 1) is a potent and selective Tpl2 (COT kinase, MAP3K8) inhibitor, plays an important role in the regulation of the inflammatory response and the progression of some cancers[1].
Related Catalog
Target

MAP3K8

In Vitro Cancer Osaka thyroid (COT) kinase (Tpl2) is an important regulator of pro-inflammatory cytokines in macrophages[1].
References

[1]. Glatthar R, et al. Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors. J Med Chem. 2016 Aug 25;59(16):7544-60.

 Chemical & Physical Properties

Molecular Formula C21H14ClFN6
Molecular Weight 404.82700
Exact Mass 404.09500
PSA 86.52000
LogP 5.19068
InChIKey NMEUKWOOQOHUNA-UHFFFAOYSA-N
SMILES N#Cc1cnc2cnc(NCc3cccnc3)cc2c1Nc1ccc(F)c(Cl)c1

 Safety Information

HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile
Tpl2 Kinase Inhibitor
4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-6-[(3-PYRIDINYLMETHYL)AMINO]-1,7-NAPHTHYRIDINE-3-CARBONITRILE
4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here



Get all suppliers and price by the below link:

TC-S 7006 suppliers


Price: ¥1700/1 mg

Reference only. check more TC-S 7006 price