CDK4/6-IN-5

Modify Date: 2024-01-02 12:02:27

CDK4/6-IN-5 Structure
CDK4/6-IN-5 structure
Common Name CDK4/6-IN-5
CAS Number 2380321-50-4 Molecular Weight 527.01
Density N/A Boiling Point N/A
Molecular Formula C22H28ClFN6O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CDK4/6-IN-5


CDK4/6-IN-5 is a potent CDK4 and CDK6 inhibitor with Kis of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1]. (from patent WO2019207463A1 example A93).

 Names

Name CDK4/6-IN-5

 CDK4/6-IN-5 Biological Activity

Description CDK4/6-IN-5 is a potent CDK4 and CDK6 inhibitor with Kis of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1]. (from patent WO2019207463A1 example A93).
Related Catalog
In Vitro The CDK4 and CDK6 cell-based IC50s of CDK4/6-IN-5 in JEKO-1 and MV4-1 1 cells are 23.8 and 61.4 nM, respectively[1].
References

[1]. Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.

 Chemical & Physical Properties

Molecular Formula C22H28ClFN6O4S
Molecular Weight 527.01