1169694-98-7

1169694-98-7 structure

Name: CDK4/6-IN-16
Chemical Name: 2-{[(1-{6-[(9-Cyclopentyl-8-fluoro-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl}-4-piperidinyl)methyl]amino}ethanol
CAS Number: 1169694-98-7
Molecular Formula: C₂₇H₃₃FN₈O
Molecular Weight: 504.602
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2018-07-21 09:14:31
Modify Date: 2024-02-05 23:05:58
CDK4/6-IN-16 (example 195) is a potent CDK4 and CDK6 inhibitor, with an IC50 of 0.013 μM for CDK4. CDK4/6-IN-16 can be used for the research of CDK4-mediated disorders, such as cancer[1].

Name	2-{[(1-{6-[(9-Cyclopentyl-8-fluoro-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl}-4-piperidinyl)methyl]amino}ethanol
Synonyms	Ethanol, 2-[[[1-[6-[(9-cyclopentyl-8-fluoro-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-4-piperidinyl]methyl]amino]- 2-{[(1-{6-[(9-Cyclopentyl-8-fluoro-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl}-4-piperidinyl)methyl]amino}ethanol

Description	CDK4/6-IN-16 (example 195) is a potent CDK4 and CDK6 inhibitor, with an IC50 of 0.013 μM for CDK4. CDK4/6-IN-16 can be used for the research of CDK4-mediated disorders, such as cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK4:13 nM (IC50) CDK6
References	[1]. Richard V. Connors, et al. Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors. WO2009085185A1.