1169694-98-7

1169694-98-7 structure
1169694-98-7 structure
  • Name: CDK4/6-IN-16
  • Chemical Name: 2-{[(1-{6-[(9-Cyclopentyl-8-fluoro-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl}-4-piperidinyl)methyl]amino}ethanol
  • CAS Number: 1169694-98-7
  • Molecular Formula: C27H33FN8O
  • Molecular Weight: 504.602
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
  • Create Date: 2018-07-21 09:14:31
  • Modify Date: 2024-02-05 23:05:58
  • CDK4/6-IN-16 (example 195) is a potent CDK4 and CDK6 inhibitor, with an IC50 of 0.013 μM for CDK4. CDK4/6-IN-16 can be used for the research of CDK4-mediated disorders, such as cancer[1].

Name 2-{[(1-{6-[(9-Cyclopentyl-8-fluoro-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl}-4-piperidinyl)methyl]amino}ethanol
Synonyms Ethanol, 2-[[[1-[6-[(9-cyclopentyl-8-fluoro-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-4-piperidinyl]methyl]amino]-
2-{[(1-{6-[(9-Cyclopentyl-8-fluoro-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl}-4-piperidinyl)methyl]amino}ethanol
Description CDK4/6-IN-16 (example 195) is a potent CDK4 and CDK6 inhibitor, with an IC50 of 0.013 μM for CDK4. CDK4/6-IN-16 can be used for the research of CDK4-mediated disorders, such as cancer[1].
Related Catalog
Target

CDK4:13 nM (IC50)

CDK6

References

[1]. Richard V. Connors, et al. Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors. WO2009085185A1.

Density 1.5±0.1 g/cm3
Boiling Point 729.5±70.0 °C at 760 mmHg
Molecular Formula C27H33FN8O
Molecular Weight 504.602
Flash Point 395.0±35.7 °C
Exact Mass 504.276123
LogP 1.86
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.735