2649120-20-5
2649120-20-5 structure
- Name: CDK4/6-IN-7
- Chemical Name: CDK4/6-IN-7
- CAS Number: 2649120-20-5
- Molecular Formula: C18H18ClN5O3
- Molecular Weight: 387.82
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2022-08-31 18:14:15
- Modify Date: 2025-08-24 21:58:56
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CDK4/6-IN-7 is a potent, selective and orally active CDK4/6 inhibitor, with IC50s of 1.58 and 4.09 nM, respectively. CDK4/6-IN-7 can be used for the research of breast cancer[1].
| Name | CDK4/6-IN-7 |
|---|
| Description | CDK4/6-IN-7 is a potent, selective and orally active CDK4/6 inhibitor, with IC50s of 1.58 and 4.09 nM, respectively. CDK4/6-IN-7 can be used for the research of breast cancer[1]. |
|---|---|
| Related Catalog | |
| Target |
CDK4:1.58 nM (IC50) CDK6:4.09 nM (IC50) |
| In Vitro | CDK4/6-IN-7 (compound 7c) (0.1-656.1 µM; 48 h) inhibits the viability of MCF-7 cells, with an IC50 of 0.92 μM[1]. Cell Proliferation Assay[1] Cell Line: MCF-7 cells Concentration: 0.1, 0.3, 0.9, 2.7, 8.1, 24.3, 72.9, 218.7, 656.1 µM Incubation Time: 48 hours Result: Inhibited MCF-7 cells growth, with an IC50 of 0.92 μM. |
| In Vivo | CDK4/6-IN-7 (compound 7c) (50 mg/kg; p.o. once daily for 7d) strongly reduces tumor growth rates in MCF-7 tumor-bearing mice[1]. Animal Model: Female nude mice (5 weeks) bearing MCF-7 tumor[1] Dosage: 50 mg/kg Administration: Oral gavage once daily for 7 days Result: Inhibited tumor growth with the tumor inhibition rate of 57.68% and was well tolerated. |
| References |
| Molecular Formula | C18H18ClN5O3 |
|---|---|
| Molecular Weight | 387.82 |