1800506-48-2
1800506-48-2 structure
- Name: CDK4/6-IN-2
- Chemical Name: CDK4/6-IN-2
- CAS Number: 1800506-48-2
- Molecular Formula: C27H32F2N8
- Molecular Weight: 506.59
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2019-06-30 09:46:15
- Modify Date: 2024-01-11 00:08:21
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CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor extracted from patent US20180000819A1, Compound 1, has IC50s of 2.7 and 16 nM for CDK4 and CDK6, respectively[1].
| Name | CDK4/6-IN-2 |
|---|
| Description | CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor extracted from patent US20180000819A1, Compound 1, has IC50s of 2.7 and 16 nM for CDK4 and CDK6, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
CDK4:2.7 nM (IC50) CDK6:16 nM (IC50) |
| In Vitro | CDK4/6-IN-2 inhibits H358, H441, PC3, MV-4-11, JeKo-1, SW780, and HGC-27 cells with IC50s of 290.9, 147.8, 260.5, 139, 36.98, 162.5, and 316.4 nM, respectively[1]. |
| References |
[1]. Frank Wu, et al. Kinase inhibitor and use thereof. US20180000819A1. |
| Molecular Formula | C27H32F2N8 |
|---|---|
| Molecular Weight | 506.59 |