MD2-TLR4-IN-1

Modify Date: 2024-01-12 15:57:01

MD2-TLR4-IN-1 structure	Common Name	MD2-TLR4-IN-1
	CAS Number	2249801-12-3	Molecular Weight	421.28
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₄Cl₂N₄O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MD2-TLR4-IN-1

MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1].

Name	MD2-TLR4-IN-1
Synonym	More Synonyms

Description	MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Cancer Research Areas >> Inflammation/Immunology
Target	MD2-TLR4[1].
References	[1]. Liu Z, et al. Discovery of 3-(Indol-5-yl)-indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury. J Med Chem. 2019 Jun 13;62(11):5453-5469.

Molecular Formula	C₂₂H₁₄Cl₂N₄O
Molecular Weight	421.28

Hazard Codes	Xi

MFCD32067977

MD2-TLR4-IN-1

Use of MD2-TLR4-IN-1

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MD2-TLR4-IN-1 Biological Activity

Chemical & Physical Properties

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