MD2-TLR4-IN-1

Modify Date: 2025-08-25 20:18:01

MD2-TLR4-IN-1 structure	Common Name	MD2-TLR4-IN-1
	CAS Number	2249801-12-3	Molecular Weight	421.28
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₄Cl₂N₄O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MD2-TLR4-IN-1

MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1].

Name	MD2-TLR4-IN-1
Synonym	More Synonyms

Description	MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Cancer Research Areas >> Inflammation/Immunology
Target	MD2-TLR4[1].
References	[1]. Liu Z, et al. Discovery of 3-(Indol-5-yl)-indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury. J Med Chem. 2019 Jun 13;62(11):5453-5469.

Molecular Formula	C₂₂H₁₄Cl₂N₄O
Molecular Weight	421.28
InChIKey	AZPDJGLJPDRCDQ-UHFFFAOYSA-N
SMILES	O=C(Nc1ccc2[nH]nc(-c3ccc4[nH]ccc4c3)c2c1)c1c(Cl)cccc1Cl

Hazard Codes	Xi

MFCD32067977

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MD2-TLR4-IN-1
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Get all suppliers and price by the below link:

MD2-TLR4-IN-1 suppliers

MD2-TLR4-IN-1 price

MD2-TLR4-IN-1

Use of MD2-TLR4-IN-1

Names

MD2-TLR4-IN-1 Biological Activity

Chemical & Physical Properties

Safety Information

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.