2249801-12-3

2249801-12-3 structure

Name: MD2-TLR4-IN-1
Chemical Name: MD2-TLR4-IN-1
CAS Number: 2249801-12-3
Molecular Formula: C₂₂H₁₄Cl₂N₄O
Molecular Weight: 421.28
Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
Create Date: 2019-08-03 18:17:59
Modify Date: 2025-08-25 20:18:01
MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1].

Name	MD2-TLR4-IN-1
Synonyms	MFCD32067977

Description	MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Cancer Research Areas >> Inflammation/Immunology
Target	MD2-TLR4[1].
References	[1]. Liu Z, et al. Discovery of 3-(Indol-5-yl)-indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury. J Med Chem. 2019 Jun 13;62(11):5453-5469.

Molecular Formula	C₂₂H₁₄Cl₂N₄O
Molecular Weight	421.28

Hazard Codes	Xi