300551-49-9

300551-49-9 structure

300551-49-9 structure

Name: Sorbitol dehydrogenase-IN-1
Chemical Name: Sorbitol dehydrogenase-IN-1
CAS Number: 300551-49-9
Molecular Formula: C₁₇H₂₅N₇O
Molecular Weight: 343.43
Catalog: Research Areas Metabolic Disease
Create Date: 2023-04-06 18:41:43
Modify Date: 2024-04-06 11:52:33
Sorbitol dehydrogenase-IN-1 is a potent and orally active sorbitol dehydrogenase inhibitor with IC50 s of 4, 5 nM for rat and human, respectively[1].

Name	Sorbitol dehydrogenase-IN-1

Description	Sorbitol dehydrogenase-IN-1 is a potent and orally active sorbitol dehydrogenase inhibitor with IC50 s of 4, 5 nM for rat and human, respectively[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	Sorbitol Dehydrogenase[1]
In Vivo	Sorbitol dehydrogenase-IN-1 (compound 16) (50 µg/kg；口服) 在慢性糖尿病大鼠中表现出对坐骨神经果糖的持续抑制作用[1]。
References	[1]. Mylari BL, et al. A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol. J Med Chem. 2002 Sep 26;45(20):4398-401.

Molecular Formula	C₁₇H₂₅N₇O
Molecular Weight	343.43