Aurora A/PKC-IN-1

Modify Date: 2025-08-26 16:59:32

Aurora A/PKC-IN-1 Structure
Aurora A/PKC-IN-1 structure
Common Name Aurora A/PKC-IN-1
CAS Number 2143100-98-3 Molecular Weight 464.24
Density N/A Boiling Point N/A
Molecular Formula C16H14N6OSe2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Aurora A/PKC-IN-1


Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC50s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity[1].

 Names

Name Aurora A/PKC-IN-1

 Aurora A/PKC-IN-1 Biological Activity

Description Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC50s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity[1].
Related Catalog
Target

Aurora A:6.9 nM (IC50)

PKCα:16.9 nM (IC50)

References

[1]. Bijian K, et al. Novel Aurora A and Protein Kinase C (α, β1, β2, and θ) Multitarget Inhibitors: Impact of Selenium Atoms on the Potency and Selectivity. J Med Chem. 2022;65(4):3134-3150.

 Chemical & Physical Properties

Molecular Formula C16H14N6OSe2
Molecular Weight 464.24
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