Aurora A/PKC-IN-1

Modify Date: 2024-01-09 23:24:55

Aurora A/PKC-IN-1 structure	Common Name	Aurora A/PKC-IN-1
	CAS Number	2143100-98-3	Molecular Weight	464.24
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₄N₆OSe₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Aurora A/PKC-IN-1

Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC50s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity[1].

Name	Aurora A/PKC-IN-1

Description	Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC50s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Aurora Kinase Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase Signaling Pathways >> TGF-beta/Smad >> PKC
Target	Aurora A:6.9 nM (IC50) PKCα:16.9 nM (IC50)
References	[1]. Bijian K, et al. Novel Aurora A and Protein Kinase C (α, β1, β2, and θ) Multitarget Inhibitors: Impact of Selenium Atoms on the Potency and Selectivity. J Med Chem. 2022;65(4):3134-3150.

Molecular Formula	C₁₆H₁₄N₆OSe₂
Molecular Weight	464.24

DC Chemicals Limited
China
Product Name: Aurora A/PKC-IN-1
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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