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Aurora A/PKC-IN-1

Names

[ CAS No. ]:
2143100-98-3

[ Name ]:
Aurora A/PKC-IN-1

Biological Activity

[Description]:

Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC50s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Aurora Kinase
Signaling Pathways >> Epigenetics >> PKC
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase
Signaling Pathways >> TGF-beta/Smad >> PKC

[Target]

Aurora A:6.9 nM (IC50)

PKCα:16.9 nM (IC50)


[References]

[1]. Bijian K, et al. Novel Aurora A and Protein Kinase C (α, β1, β2, and θ) Multitarget Inhibitors: Impact of Selenium Atoms on the Potency and Selectivity. J Med Chem. 2022;65(4):3134-3150.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H14N6OSe2

[ Molecular Weight ]:
464.24

Related Compounds