2143100-98-3

2143100-98-3 structure

Name: Aurora A/PKC-IN-1
Chemical Name: Aurora A/PKC-IN-1
CAS Number: 2143100-98-3
Molecular Formula: C₁₆H₁₄N₆OSe₂
Molecular Weight: 464.24
Create Date: 2022-05-20 20:20:35
Modify Date: 2024-01-09 23:24:55
Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC50s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity[1].

Name	Aurora A/PKC-IN-1

Description	Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC50s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Aurora Kinase Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase Signaling Pathways >> TGF-beta/Smad >> PKC
Target	Aurora A:6.9 nM (IC50) PKCα:16.9 nM (IC50)
References	[1]. Bijian K, et al. Novel Aurora A and Protein Kinase C (α, β1, β2, and θ) Multitarget Inhibitors: Impact of Selenium Atoms on the Potency and Selectivity. J Med Chem. 2022;65(4):3134-3150.

Molecular Formula	C₁₆H₁₄N₆OSe₂
Molecular Weight	464.24