1158838-45-9
1158838-45-9 structure
- Name: Aurora A Inhibitor I
- Chemical Name: N-(2-chlorophenyl)-4-[[2-[4-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]anilino]-5-fluoropyrimidin-4-yl]amino]benzamide
- CAS Number: 1158838-45-9
- Molecular Formula: C31H31ClFN7O2
- Molecular Weight: 588.075
- Catalog: Biochemical Inhibitor Cell Cycle Aurora Kinase Inhibitor
- Create Date: 2018-10-13 19:31:22
- Modify Date: 2025-08-25 19:58:44
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Aurora A inhibitor I is a potent and highly selective Aurora A inhibitor with with an IC50 of 3.4 nM.
| Name | N-(2-chlorophenyl)-4-[[2-[4-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]anilino]-5-fluoropyrimidin-4-yl]amino]benzamide |
|---|---|
| Synonyms |
Aurora-A Inhibitor I
N-(2-Chlorophenyl)-4-{[2-({4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl}amino)-5-fluoro-4-pyrimidinyl]amino}benzamide Aurora A inhibitor 1 2,4-Bisanilinopyrimidine,10 Aurora A Inhibitor I N-(2-chlorophenyl)-4-{[2-({4-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]phenyl}amino)-5-fluoropyrimidin-4-yl]amino}benzamide N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]benzamide S1451_Selleck HMS3265K21 |
| Description | Aurora A inhibitor I is a potent and highly selective Aurora A inhibitor with with an IC50 of 3.4 nM. |
|---|---|
| Related Catalog | |
| Target |
Aurora A:3.4 nM (IC50) Aurora B:3.4 μM (IC50) |
| In Vitro | Aurora A inhibitor I is exceptionally selective Aurora A inhibitors. Aurora A inhibitor I is an useful tool compounds for investigating the cellular role of Aurora A kinases without the complication of also inhibiting Aurora B[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C31H31ClFN7O2 |
| Molecular Weight | 588.075 |
| Exact Mass | 587.221191 |
| PSA | 102.49000 |
| LogP | 4.39 |
| Appearance | white to beige |
| Index of Refraction | 1.679 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: soluble10mg/mL, clear |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Hazard Codes | Xn |
| Risk Phrases | 22 |
| RIDADR | NONH for all modes of transport |
| Precursor 2 | |
|---|---|
| DownStream 0 | |