GPR120 Compound A

Modify Date: 2024-01-11 09:53:58

GPR120 Compound A structure	Common Name	GPR120 Compound A
	CAS Number	1599477-75-4	Molecular Weight	405.83900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₃ClF₃NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GPR120 Compound A

GPR120-IN-1 is a selective Gpr120 agonist with a logEC50 of −7.62.

Name	2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5]undecan-9-yl)acetic acid
Synonym	More Synonyms

Description	GPR120-IN-1 is a selective Gpr120 agonist with a logEC50 of −7.62.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GPR120 Research Areas >> Metabolic Disease
Target	logEC50: −7.62[1]
In Vitro	GPR120-IN-1 is fully selective for Gpr120 (logEC50=−7.62) with negligible activity towards Gpr40. GPR120-IN-1 produces concentration dependent increases in IP3 production from both human and mouse Gpr120 expressing cells. GPR120-IN-1 leads to a concentration-dependent response to recruit β-arrestin-2 in both human and mouse Gpr120 expressing cells, with EC50s of ~0.35 μM. GPR120-IN-1 strongly and comparably inhibits LPS-induced phosphorylation of Tak1, Ikkβ, and Jnk and blocked IκB degradation [1].
In Vivo	GPR120-IN-1 causes improved insulin sensitivity with increased glucose infusion rates, enhanced insulin stimulated-glucose disposal rate, along with a marked increase in the ability of insulin to suppress hepatic glucose production only in WT mice. GPR120-IN-1 treatment has beneficial effects on hepatic lipid metabolism, causing decreased hepatic steatosis, decreased liver triglycerides, and DAGs, along with reduced saturated free fatty acid conten[1].
Animal Admin	Mice: Male C57Bl/6 WT or Gpr120 KO littermates are fed a normal chow (13.5% fat) or high-fat diet (60% fat) ad libitum for 15-20 weeks from 8 weeks of age. After 15 weeks on HFD, WT and Gpr120 KO mice are switched to an isocaloric HFD supplemented with ω3-FA concentrate or 30 mg/kg GPR120-IN-1 and fed for 5 weeks. Mice receive fresh diet every 3rd day, and food consumption and body weight are monitored[1].
References	[1]. Oh DY, et al. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat Med. 2014 Aug;20(8):942-7.

Molecular Formula	C₁₉H₂₃ClF₃NO₃
Molecular Weight	405.83900
Exact Mass	405.13200
PSA	49.77000
LogP	5.55510
Storage condition	2-8℃

GPR120 Compound A

GPR120-IN-1

DC Chemicals Limited
China
Product Name: GPR120 Compound A
Price: $600.0/100mg $1200.0/250mg $2500.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: GPR120 Compound A
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $145/10mM*1mLinDMSO

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