APJ receptor agonist 5

Modify Date: 2024-01-12 21:44:11

APJ receptor agonist 5 Structure
APJ receptor agonist 5 structure
Common Name APJ receptor agonist 5
CAS Number 2135514-20-2 Molecular Weight 479.52
Density N/A Boiling Point N/A
Molecular Formula C26H29N3O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of APJ receptor agonist 5


APJ receptor agonist 5 (compound 3) is a potent and orally active agonist of apelin receptor (APJ) with an EC50 of 0.4 nM. APJ receptor agonist 5 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 5 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 5 leads to improved cardiac function and can be used for researching the HF disease[1].

 Names

Name APJ receptor agonist 5

 APJ receptor agonist 5 Biological Activity

Description APJ receptor agonist 5 (compound 3) is a potent and orally active agonist of apelin receptor (APJ) with an EC50 of 0.4 nM. APJ receptor agonist 5 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 5 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 5 leads to improved cardiac function and can be used for researching the HF disease[1].
Related Catalog
References

[1]. Meng W, et al. Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure. J Med Chem. 2021;64(24):18102-18113.

 Chemical & Physical Properties

Molecular Formula C26H29N3O6
Molecular Weight 479.52
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